Double procedure may keep AFib away longer
NCT ID NCT07320768
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding a nerve-calming kidney procedure (renal denervation) to standard heart ablation (pulsed-field ablation) can better prevent atrial fibrillation from coming back. About 86 adults with persistent AFib will be randomly assigned to get either the combination or ablation alone. The main goal is to see if the combo keeps the heart in normal rhythm for at least 12 months without needing antiarrhythmic drugs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- renal denervation and pulsed-field ablation (both catheter-based procedures)
- What this could lead to
- If successful, this combination procedure could reduce the chance of atrial fibrillation coming back after ablation, potentially decreasing the need for repeat procedures or long-term medication.
- What could go wrong
- This is a small, early-stage trial (86 participants) and results may not apply to everyone. The procedures carry risks like bleeding, blood vessel damage, or heart rhythm issues.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Shanghai Chest Hospital
Shanghai, 200030, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Which ablation method best tames persistent AF? a Head-to-Head trial aims to find out
- Extra ablation target may cut AF recurrence in persistent cases
- New heart ablation tech under scrutiny: can it tame dangerous rhythms?
- New 3D heart imaging could sharpen ablation precision
- More zaps, better rhythm? trial tests extra ablations for AFib
- Could a gentle electric field heal the heart? new study tests Pulsed-Field ablation for persistent AF