PERSISTENT ATRIAL FIBRILLATION

This study tests whether adding a kidney nerve treatment (renal denervation) to a repeat heart ablation procedure can better prevent atrial fibrillation from coming back. About 250 adults with high blood pressure who need a second ablation will be randomly assigned to get ablatio…

This study is testing a new device called FARAFLEX that uses pulsed field ablation to treat people with persistent or occasional atrial fibrillation (an irregular heartbeat). About 250 adults will receive the procedure to see if it is safe and can successfully isolate the heart a…

This study tests whether a catheter ablation procedure is better than electrical cardioversion at preventing persistent atrial fibrillation from coming back. About 208 adults with AF lasting over 7 days but less than 2 years will be randomly assigned to one of the two treatments.…

This study is for people with persistent atrial fibrillation (a type of irregular heartbeat lasting more than 7 days but less than a year) who haven't gotten relief from medication. It will test a new catheter system designed to burn away the tissue causing the problem. Researche…

This study tests whether adding a 'linear ablation' (creating extra scar lines in the heart) to the standard pulmonary vein isolation procedure helps people with persistent atrial fibrillation stay in normal heart rhythm longer. About 640 adults aged 18-80 with symptomatic, drug-…

This study tests if using a special device to burn small areas of heart tissue during open-heart surgery can stop a type of irregular heartbeat called persistent atrial fibrillation. About 160 people who need heart surgery for other reasons will take part. The goal is to see if t…

This study is testing a new device called the Volt PFA System to treat people with atrial fibrillation (AFib), a condition where the heart beats irregularly. The study will enroll 300 adults with paroxysmal (comes and goes) or persistent (lasts more than 7 days) AFib. The main go…

This study looks at whether a heart procedure called catheter ablation can slow or improve memory and thinking in people aged 60-80 who have both persistent atrial fibrillation (an irregular heartbeat) and mild cognitive impairment (early memory loss). About 120 participants will…

This study looks at whether a reduced dose of the heart medication amiodarone can keep the heart beating normally after an electrical shock procedure for persistent atrial fibrillation. About 312 adults with this condition will take a standard dose for one month, then either cont…

This study tests a new way to treat persistent atrial fibrillation (a type of irregular heartbeat) in people who have already had one ablation procedure. About 376 adults will receive a repeat procedure using the FARAPULSE system, which uses electrical pulses to fix the heart's e…

This study tests if a two-step hybrid ablation procedure works better than standard catheter ablation for controlling persistent atrial fibrillation in people with heart failure. About 120 adults with an enlarged left atrium and reduced heart pumping function will be randomly ass…

This early study tests a new catheter that changes shape to better treat persistent atrial fibrillation (AF), a type of irregular heartbeat. About 40 adults with persistent AF will receive this treatment under general anesthesia. The goal is to see if the catheter is safe within …

This study tests new energy waveforms from the FARAPULSE system to treat atrial fibrillation (AFib), a common heart rhythm problem. About 200 adults with intermittent or persistent AFib will receive a minimally invasive procedure to isolate abnormal electrical signals in the hear…

This study tests a new catheter system (Sphere-9 and Affera) for a repeat heart ablation procedure in 400 people whose atrial fibrillation (AFib) came back after a first ablation. Participants will have the procedure and be followed for 12 months to see if it safely restores norm…

This study tests a new mapping system (CoreMap) to help doctors treat persistent atrial fibrillation (AFib), a type of irregular heartbeat. About 245 adults with persistent AFib will have a standard ablation procedure guided by this system. The goal is to see if it safely and eff…

This study tests whether Qidong Yixin Granules, a Chinese herbal medicine, can reduce the chance of atrial fibrillation returning within a year after a heart ablation procedure. About 846 adults with persistent atrial fibrillation will be randomly assigned to take either the herb…

This study is testing three different approaches to a heart procedure called catheter ablation for people with persistent atrial fibrillation (a long-lasting irregular heartbeat). Researchers are using a special catheter that can deliver two types of energy to create small scars …

This study is a registry that will track the safety and success of a heart procedure called pulsed field ablation (PFA) in 275 minority patients with atrial fibrillation (an irregular heartbeat). The goal is to see how well the procedure works and if it is safe for this group. Pa…

This study tests a new paddle-shaped catheter designed to map abnormal heart rhythms (arrhythmias) in people with conditions like atrial fibrillation or ventricular tachycardia. About 60 participants will undergo a standard heart-mapping procedure using this investigational devic…

This study looks at whether it's possible to run a larger trial comparing two types of exercise (moderate continuous training and high-intensity interval training) to a week of rest in people with atrial fibrillation (AF). The goal is to see if exercise can reduce AF symptoms lik…