PERSISTENT ATRIAL FIBRILLATION

This study compares two treatments for persistent atrial fibrillation (AF), a heart rhythm problem. One treatment is catheter ablation, which uses heat to destroy tiny areas of heart tissue causing the irregular rhythm. The other is electrical cardioversion, which delivers a cont…

This study tests whether adding a kidney nerve treatment (renal denervation) to a repeat heart ablation procedure can better prevent atrial fibrillation from coming back. It involves 250 adults with high blood pressure who need a second ablation. Participants are randomly assigne…

This study looks at whether treating a common heart rhythm problem (atrial fibrillation) with a procedure called catheter ablation can help slow down memory loss in people who already have mild thinking difficulties. About 120 adults aged 60 to 80 with both conditions will be ran…

This study is testing a new device called the Volt PFA System, which uses balloon-based energy to treat atrial fibrillation (AF), a common heart rhythm problem. Researchers will enroll 300 people with paroxysmal or persistent AF to see how safe and effective the procedure is in r…

This study tests new energy waveforms from the FARAPULSE system to treat atrial fibrillation, a common heart rhythm problem. About 200 adults with either short-term or persistent AFib will receive the procedure. The goal is to see if the new waveforms can safely and effectively i…

This study compares two types of heart procedures—convergent hybrid ablation and standard catheter ablation—in 120 adults with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. The goal is to see which approach better controls heart rhythm without …

This study tests a new catheter system (Sphere-9 and Affera) for a repeat heart ablation procedure in people whose atrial fibrillation (AFib) came back after a first ablation. About 400 adults with recurrent symptomatic AFib will get the procedure and be followed for 12 months to…

This study compares two doses of the heart medication amiodarone in people with persistent atrial fibrillation (an irregular heartbeat) after they receive an electrical shock to restore normal rhythm. The goal is to see if a lower daily dose (100 mg) works as well as the standard…

This study tests a new catheter that changes shape to better treat persistent atrial fibrillation, a type of irregular heartbeat. About 40 adults with this condition will receive the treatment under general anesthesia. The goal is to see if the catheter is safe and can create las…

This study tests a new device called FARAFLEX that uses pulsed field ablation to treat people with persistent or occasional atrial fibrillation (an irregular heartbeat). About 250 adults will receive either the new catheter or a standard one to see if it safely and effectively cr…

This study compares two heart procedures for people with persistent atrial fibrillation (a type of irregular heartbeat). One group gets the standard treatment (pulmonary vein isolation) plus an extra step (linear ablation), while the other gets standard treatment alone. The goal …

This study tests a new way to treat persistent atrial fibrillation (a type of irregular heartbeat) in people who have already had one ablation procedure. The treatment uses a special catheter to deliver targeted energy to the heart to fix the electrical problem. The study will en…

This study compares three different ablation techniques for people with persistent atrial fibrillation (a type of irregular heartbeat). Using a special catheter that can switch between two energy types, doctors will see if adding extra ablation areas improves results. The trial w…

This study tests if using a special device to burn tiny spots in the heart can stop long-lasting atrial fibrillation (AFib) in people already having open-heart surgery. About 160 adults with persistent AFib will get the treatment. The goal is to see if the heart stays in normal r…

This study tests a new mapping system (CoreMap) to help doctors treat persistent atrial fibrillation (AFib), a type of irregular heartbeat. About 245 adults with persistent AFib will have a standard ablation procedure guided by this system. The goal is to see if it safely and eff…

This study tests whether Qidong Yixin Granules, a Chinese herbal medicine, can reduce the chance of atrial fibrillation returning within a year after a standard heart ablation procedure. About 846 adults with persistent atrial fibrillation will be randomly assigned to take either…

This study looks at whether it's possible to run a larger trial comparing how different types of exercise (moderate or high intensity) affect symptoms of atrial fibrillation (AFib) compared to a week of rest. About 36 adults with AFib who have symptoms will try each approach. The…

This study is testing a new paddle-shaped catheter designed to map abnormal heart rhythms (arrhythmias) in the upper and lower chambers of the heart. About 60 people with conditions like atrial fibrillation or ventricular tachycardia will take part. The main goal is to check if t…

This study is a registry that will track the safety and success of a procedure called pulsed field ablation (PFA) for treating atrial fibrillation (an irregular heartbeat) in people from racial and ethnic minority groups. About 275 participants will be followed for one year to se…