PERSISTENT ATRIAL FIBRILLATION

This study tests a procedure called pulsed field ablation (PFA) for people with early-stage atrial fibrillation (AFib) diagnosed within the last 3 years. The procedure uses a balloon to deliver energy that isolates the pulmonary veins, aiming to stop abnormal heart rhythms. Resea…

This trial tests whether ezetimibe, a common cholesterol-lowering medication, can reduce the return of irregular heartbeats in people with persistent atrial fibrillation who undergo catheter ablation. Half of the 120 participants will take ezetimibe daily for six months after the…

This clinical trial tests whether giving two electrical shocks at once (dual shock) is better than the standard single shock for restoring normal heart rhythm in people with persistent atrial fibrillation. About 177 participants will be randomly assigned to receive either a stand…

This study tests a new imaging and guidance system called VERAFEYE that creates a 3D model of the heart to help doctors navigate during catheter ablation for atrial fibrillation. About 50 adults with paroxysmal or persistent atrial fibrillation will have their standard ablation p…

This study looks at whether pulsed-field ablation (PFA), a non-thermal technique that uses electric pulses to target faulty heart tissue, can reverse structural changes in the heart caused by persistent atrial fibrillation (AF). Researchers will enroll 30 people with persistent A…

This trial tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce the return of atrial fibrillation (AFib) after a heart procedure called catheter ablation. Overweight or obese adults with persistent AFib will receive either tirzepatide injections plus st…

This study tests whether a new catheter ablation system using pulsed field energy can better control persistent atrial fibrillation (AF) by targeting low-voltage areas in the heart and isolating the superior vena cava, in addition to standard pulmonary vein isolation. About 618 a…

This study tests whether adding extra ablation to standard treatment can help people with persistent atrial fibrillation (a type of irregular heartbeat). About 350 adults will be randomly assigned to receive either standard ablation or standard ablation plus isolation of the left…

This study compares two heart procedures for people with persistent atrial fibrillation (AFib) lasting 6 months to 3 years. One group gets standard pulmonary vein isolation (PVI) ablation, while the other gets PVI plus an extra ablation on the Bachmann bundle. The goal is to see …

This study tests a new device that uses short electrical pulses to treat atrial fibrillation (AF), a common heart rhythm problem. About 320 adults with AF will receive this procedure to see if it safely restores normal heart rhythm for at least a year. The goal is to reduce sympt…

This study tests whether adding acupuncture to standard care can reduce the return of irregular heartbeats in people with persistent atrial fibrillation who have already had a catheter ablation. About 120 adults aged 20 to 75 will be randomly assigned to receive either acupunctur…

This study compares two ablation procedures for people with persistent atrial fibrillation (AF), a heart rhythm problem. Half of the 450 participants will get standard treatment (isolating the pulmonary veins), while the other half will get extra ablation lines in the heart. The …

This trial tests whether dapagliflozin, a drug typically used for diabetes, can reduce the return of atrial fibrillation after a heart ablation procedure. The study focuses on patients with persistent AF and increased epicardial adipose tissue (heart fat), which is linked to high…

This study tests a new shape-adaptive catheter that uses pulsed field ablation to treat persistent atrial fibrillation (AFib), a type of irregular heartbeat. 35 adults with persistent AFib will receive the procedure under general anesthesia. Researchers will check for serious sid…

This study tests if burning extra spots outside the main heart veins can better control persistent atrial fibrillation (a type of irregular heartbeat). About 406 adults having their first ablation will be split into two groups: one gets standard vein isolation, the other gets add…

This study tests a new exercise approach for people aged 60 and older who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF. Instead of starting with aerobic exercise like walking, participants will first do 2 months of progressive re…

This study looks at 150 people with persistent atrial fibrillation (a type of irregular heartbeat) who are scheduled for a heart procedure called ablation. Researchers want to see if levels of a protein called BDNF in the blood are linked to signs of heart muscle damage (atrial c…

This study compares two types of heart ablation for people with persistent atrial fibrillation: pulsed field ablation and radiofrequency ablation. The goal is to see which one causes fewer stomach problems after the procedure. Twenty participants will be matched by age and health…

This study will compare five different pulsed field ablation systems used to treat atrial fibrillation (an irregular heartbeat). The goal is to see which system causes the fewest tiny clots (microemboli) that travel to the brain during the procedure. One hundred adults with atria…

This study looks at 40 adults with atrial fibrillation and heart failure to see if lowering their resting heart rate from 100-110 bpm to a more normal level improves exercise ability and quality of life. Participants will do treadmill tests before and after either a cardioversion…