PERSISTENT ATRIAL FIBRILLATION

This study tests whether combining two procedures—closing the left atrial appendage and using pulsed field ablation to correct heart rhythm—works better than closing the appendage alone in people with persistent atrial fibrillation and high stroke risk. Fifty participants will be…

This study tests whether a procedure called pulsed field ablation (PFA) is safer and more effective than anti-arrhythmic drugs as a first treatment for people with persistent atrial fibrillation, a type of irregular heartbeat. About 484 participants will be randomly assigned to r…

This study follows 200 adults with persistent atrial fibrillation (a type of irregular heartbeat lasting more than 7 days but less than a year) who are treated with the Sphere-9 catheter and Affera ablation system. The goal is to see how safe the procedure is and how well it prev…

This study tests whether a personalized catheter ablation approach, guided by mapping low-voltage areas in the heart, works better than standard ablation for people with persistent atrial fibrillation (AFib). About 510 adults with persistent AFib will be randomly assigned to rece…

This study tests whether adding a nerve-calming kidney procedure (renal denervation) to standard heart ablation (pulsed-field ablation) can better prevent atrial fibrillation from coming back. About 86 adults with persistent AFib will be randomly assigned to get either the combin…

This study looks at a procedure called cryoablation that uses a freezing balloon to destroy tiny areas of heart tissue causing an irregular heartbeat (persistent atrial fibrillation). About 400 adults with this condition will be followed for up to 3 years to see how well the trea…

This study compares three catheter ablation techniques for people with persistent atrial fibrillation (AF), a heart rhythm disorder. About 617 adults having their first ablation will be randomly assigned to one of three groups: isolating the pulmonary veins alone, adding ablation…

This pilot study tests whether using advanced imaging (ECGI, MRI, and PET scans) to identify abnormal heart tissue and electrical circuits can improve catheter ablation for persistent atrial fibrillation. Fifty-two adults with persistent AF who have not had prior ablation will re…

This study tests a new device system that uses pulsed electric fields to treat atrial fibrillation, a common heart rhythm problem. About 300 people with symptomatic, recurrent atrial fibrillation will receive the procedure. The goal is to see if it safely and effectively restores…

This study tests a device called the Farapulse system, which uses electrical pulses to treat atrial fibrillation (AFib), a common heart rhythm problem. Researchers will enroll 275 adults with AFib who are already scheduled for a catheter ablation procedure. The goal is to see if …

This study tests whether a new drug called Refralon, taken as a tablet once or twice daily, can prevent atrial fibrillation or flutter from returning after normal heart rhythm has been restored. About 175 adults with persistent AFib will receive either Refralon or a placebo for 6…

This study tests a catheter ablation procedure for people with persistent or long-standing persistent atrial fibrillation, a type of irregular heartbeat that is hard to treat. The procedure uses electroporation and radiofrequency energy to create scars in the heart that block abn…

This study tests whether adding extra ablation to the back wall of the heart's left atrium improves outcomes for people with persistent atrial fibrillation (a type of irregular heartbeat). About 206 participants will receive either standard vein isolation or vein isolation plus b…

This study compares two ways to repeat a heart ablation for people with persistent atrial fibrillation (AF) whose first ablation didn't work. The standard repeat method isolates the pulmonary veins; the experimental method also treats the left atrial posterior wall. Researchers w…

This study tests two different ablation techniques using a new, safer method called pulsed-field ablation (PFA) in 300 adults with persistent atrial fibrillation (a type of irregular heartbeat). One group gets standard vein isolation, while the other gets additional targeted burn…

This study compares two types of ablation—pulse field and radiofrequency—for treating persistent atrial fibrillation, a common heart rhythm problem. Fifty participants will receive one of the two procedures to isolate faulty electrical areas in the heart. The goal is to see which…

This study tests a new device called the Globe Pulsed Field System to treat people with atrial fibrillation (AF), a common heart rhythm problem. The device uses electrical pulses to destroy small areas of heart tissue causing the irregular rhythm. About 549 participants will be f…

This early study tests a new balloon-shaped catheter that uses pulsed electric fields to treat persistent atrial fibrillation, a type of irregular heartbeat. Thirty-four adults aged 18 to 75 with the condition will receive the procedure. Researchers will check safety within 7 day…

This study tests whether adding ablation of scarred heart tissue to standard pulmonary vein isolation helps people with persistent atrial fibrillation stay free of irregular heartbeats. Two hundred participants will be randomly assigned to one of two ablation procedures. The main…

This study follows 200 people with persistent atrial fibrillation (AF) who undergo a heart procedure using Abbott's ablation catheter. The catheter uses heat to scar tiny areas in the heart and block faulty electrical signals. Researchers track how many patients stay free of AF f…

This study tests whether using an implantable heart monitor (or a wearable patch) to detect atrial fibrillation early after catheter ablation can reduce the total time spent in AF. About 120 people with paroxysmal or persistent AF will be monitored for 15 months. The goal is to s…

This study compares two procedures for people aged 75 and older with persistent atrial fibrillation (an irregular heartbeat). One group gets a pacemaker plus ablation of the heart's electrical node, while the other gets pulmonary vein isolation using cryoenergy. The goal is to se…

This study compares three catheter ablation strategies in 300 adults with persistent atrial fibrillation and heart failure. The goal is to see which approach best reduces the risk of death, hospitalization, or urgent visits due to worsening heart failure. Participants are randoml…

This study looks at a new way to analyze electrical signals in the heart to help doctors find exactly where to burn during atrial fibrillation treatment. Researchers will review data from 336 patients who had the procedure, comparing those who stayed free of AFib for a year with …

This study looks at whether a new computer algorithm can predict if atrial fibrillation (an irregular heartbeat) will come back after a common treatment called pulmonary vein isolation. Researchers will review medical records from 300 patients who had this procedure. The goal is …

This study follows 5,000 adults in Southwest China with persistent atrial fibrillation (a type of irregular heartbeat) for up to 5 years. Researchers will collect information on patients' health, treatments, and outcomes to learn which approaches work best and why. The goal is to…

This study looks at whether actively cooling the esophagus during a common heart procedure (ablation for atrial fibrillation) helps improve outcomes and reduce side effects. Researchers will follow 312 adults with symptomatic atrial fibrillation who are already scheduled for abla…