New combo heart procedure aims to cut stroke risk and improve heart function in AF patients
NCT ID NCT07453940
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times
Summary
This study tests whether combining two procedures—closing the left atrial appendage and using pulsed field ablation to correct heart rhythm—works better than closing the appendage alone in people with persistent atrial fibrillation and high stroke risk. Fifty participants will be randomly assigned to one of the two groups and followed for six months. The goal is to see if the combination improves exercise capacity and blood flow to the brain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pulsed field ablation (PFA) using the FARAPULSE system
- What this could lead to
- If it works, this could point toward a better treatment strategy for persistent atrial fibrillation patients at high risk of stroke, potentially improving heart function and quality of life.
- What could go wrong
- This is a small pilot study with only 50 participants, so results may not apply to everyone. The combination procedure also carries risks like bleeding, infection, or heart rhythm problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sir Run Run Shaw Hospital
Hangzhou, Zhejiang, 310000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a cholesterol drug keep atrial fibrillation at bay after ablation?
- Which ablation method best tames persistent AF? a Head-to-Head trial aims to find out
- Extra ablation target may cut AF recurrence in persistent cases
- Could a One-Time keyhole surgery replace daily blood thinners for some heart patients?
- New heart ablation tech under scrutiny: can it tame dangerous rhythms?
- New 3D heart imaging could sharpen ablation precision