New combo heart procedure aims to cut stroke risk and improve heart function in AF patients
NCT ID NCT07453940
First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This study tests whether combining two procedures—closing the left atrial appendage and using pulsed field ablation to correct heart rhythm—works better than closing the appendage alone in people with persistent atrial fibrillation and high stroke risk. Fifty participants will be randomly assigned to one of the two groups and followed for six months. The goal is to see if the combination improves exercise capacity and blood flow to the brain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pulsed field ablation (PFA) using the FARAPULSE system
What this could lead to
If it works, this could point toward a better treatment strategy for persistent atrial fibrillation patients at high risk of stroke, potentially improving heart function and quality of life.
What could go wrong
This is a small pilot study with only 50 participants, so results may not apply to everyone. The combination procedure also carries risks like bleeding, infection, or heart rhythm problems.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sir Run Run Shaw Hospital
Hangzhou, Zhejiang, 310000, China