New ablation strategy may improve heart rhythm control in persistent AFib

NCT ID NCT04377594

Ongoing Disease control Sponsor: Karolinska University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding ablation of scarred heart tissue to standard pulmonary vein isolation helps people with persistent atrial fibrillation stay free of irregular heartbeats. Two hundred participants will be randomly assigned to one of two ablation procedures. The main goal is to see if the extra ablation reduces arrhythmias without needing antiarrhythmic drugs after one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radio frequency ablation
What this could lead to: If successful, this could lead to a more effective ablation procedure that reduces the need for antiarrhythmic drugs in patients with persistent atrial fibrillation.
What could go wrong: This is a mid-stage trial with 200 participants, so results may not apply to all patients. The added ablation of fibrotic areas may not improve outcomes and could carry extra risks like heart tissue damage.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION

Contacts and locations

Locations

Karolinska University Hospital

Stockholm, Stockholm County, SE-14186, Sweden

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