New ablation strategy may improve heart rhythm control in persistent AFib
NCT ID NCT04377594
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding ablation of scarred heart tissue to standard pulmonary vein isolation helps people with persistent atrial fibrillation stay free of irregular heartbeats. Two hundred participants will be randomly assigned to one of two ablation procedures. The main goal is to see if the extra ablation reduces arrhythmias without needing antiarrhythmic drugs after one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
radio frequency ablation
What this could lead to
If successful, this could lead to a more effective ablation procedure that reduces the need for antiarrhythmic drugs in patients with persistent atrial fibrillation.
What could go wrong
This is a mid-stage trial with 200 participants, so results may not apply to all patients. The added ablation of fibrotic areas may not improve outcomes and could carry extra risks like heart tissue damage.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Karolinska University Hospital
Stockholm, Stockholm County, SE-14186, Sweden