Karolinska University Hospital

This early-phase study tests a new radioactive drug, [177Lu]Lu-AKIR001, in 15 adults with advanced solid tumors (like thyroid, head and neck, cervical, vulvar, or lung cancer) that have stopped responding to standard treatments. The main goal is to check the drug's safety and sid…

This study compares robotic-assisted surgery to traditional open surgery for gallbladder cancer. About 94 patients will be randomly assigned to one of the two procedures. The main goal is to see which approach helps patients recover faster after surgery, measured by pain control,…

This phase 2 trial compares the experimental drug trastuzumab deruxtecan (T-DXd) to standard chemotherapy given before surgery for HER2-positive breast cancer. About 370 participants will receive either T-DXd or standard treatment for three cycles, then further treatment is chose…

This study follows 1,000 adults who have long-term bladder or bowel problems from past cancer radiation and are receiving hyperbaric oxygen therapy (HBOT). Researchers want to learn which patients improve most and when treatment works best. The goal is to better understand how to…

This study looks at why some people who have had a stem cell transplant feel very tired and have trouble thinking clearly. Researchers will use brain scans and spinal fluid tests to see if inflammation in the brain is the cause. The goal is to better understand these problems, no…

This study reviews medical records from over 50,000 critically ill patients to see if starting dialysis earlier helps them live longer. Researchers will compare patients who started dialysis early versus late, looking at survival up to 90 days and beyond. The goal is to find the …