Karolinska University Hospital

This early-phase study tests a new radioactive drug, [177Lu]Lu-AKIR001, in 15 adults with advanced solid tumors (like thyroid, head and neck, cervical, vulvar, or lung cancer) that have stopped responding to standard treatments. The main goal is to check the drug's safety and sid…

This study compares robotic-assisted surgery to traditional open surgery for gallbladder cancer. About 94 patients will be randomly assigned to one of the two procedures. The main goal is to see which approach helps patients recover faster after surgery, measured by pain control,…

This phase 2 trial compares the experimental drug trastuzumab deruxtecan (T-DXd) to standard chemotherapy given before surgery for HER2-positive breast cancer. About 370 participants will receive either T-DXd or standard treatment for three cycles, then further treatment is chose…

This study tests whether a newer type of CT scan, called photon-counting CT, can accurately measure blood flow to the heart muscle and detect scarring or fibrosis. Researchers will compare the CT results with cardiac MRI and invasive coronary angiography in 100 patients with aort…

This study looks at how the body's production of glucose, fat, and protein changes in critically ill patients on ventilators when they receive nutrition. Researchers will measure these changes using special labeled tracers, comparing a fasting state to a fed state. The goal is to…

This study aims to understand why some people with heart failure respond well to standard guideline-directed medical therapy while others do not. By analyzing genetic data and biomarkers from a large biobank of 5,000 patients, researchers hope to identify predictors of treatment …

This study follows 1,000 adults who have long-term bladder or bowel problems from past cancer radiation and are receiving hyperbaric oxygen therapy (HBOT). Researchers want to learn which patients improve most and when treatment works best. The goal is to better understand how to…

This study looks at why some people who have had a stem cell transplant feel very tired and have trouble thinking clearly. Researchers will use brain scans and spinal fluid tests to see if inflammation in the brain is the cause. The goal is to better understand these problems, no…

This study reviews medical records from over 50,000 critically ill patients to see if starting dialysis earlier helps them live longer. Researchers will compare patients who started dialysis early versus late, looking at survival up to 90 days and beyond. The goal is to find the …