Can a One-Two punch fix a leaky heart valve and restore normal rhythm?
NCT ID NCT07741383
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This trial tests whether combining a minimally invasive heart valve repair (TEER) with an electrical shock to restore normal heart rhythm (cardioversion) can improve outcomes for people with severe mitral regurgitation and atrial fibrillation. Participants who have already had a successful TEER will be randomly assigned to also receive cardioversion during the same procedure or to receive standard care alone. The study will track whether the combined approach reduces the chance of death, heart failure hospitalizations, or stroke within a year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Transcatheter Edge-to-Edge Repair (TEER) followed by immediate electrical cardioversion (ECV) during the same procedure
- What this could lead to
- If successful, this combined approach could reduce the risk of death, heart failure hospitalizations, and stroke in people with severe mitral regurgitation and atrial fibrillation, offering a more effective one-time strategy.
- What could go wrong
- This is an early-stage trial, and the combined procedure carries risks such as bleeding, infection, or complications from the shock. The results may not apply to all patients, and the benefit over standard care is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Second Affiliated Hospital Zhejiang University School of Medicine
RECRUITINGHangzhou, Zhejiang, 310009, China
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