Kidney ultrasound may help keep heart rhythm steady after second AFib procedure

NCT ID NCT05988411

Ongoing Disease control Sponsor: Vivek Reddy Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study tests whether adding a kidney nerve treatment (renal denervation) to a repeat catheter ablation for atrial fibrillation (AFib) can lower the chance of AFib coming back. About 250 people with high blood pressure and AFib who need a second ablation will be randomly assigned to get ablation alone or ablation plus the kidney treatment. The main goal is to see if the combination keeps the heart in normal rhythm longer without needing extra heart-rhythm drugs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Renal denervation using the Paradise ultrasound catheter
What this could lead to: If successful, this could offer a new way to lower the chance of atrial fibrillation coming back after a repeat ablation procedure, especially for people with high blood pressure.
What could go wrong: This is a small pilot study, so results are preliminary. The added procedure carries risks like any catheter-based intervention, and it may not reduce AFib recurrence more than ablation alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation hypertensive disorder paroxysmal atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAROXYSMAL ATRIAL FIBRILLATION PERSISTENT ATRIAL FIBRILLATION

Contacts and locations

Locations

Arrhythmia Research Group

Jonesboro, Arkansas, 72401, United States
Christus

Tyler, Texas, 75702, United States
Henry Ford Health System

Detroit, Michigan, 48202, United States
Los Robles Medical Center

Thousand Oaks, California, 91360, United States
Mount Sinai Hospital

New York, New York, 10029, United States
Trident Medical Center

Charleston, South Carolina, 29406, United States
UCSF

San Francisco, California, 94143, United States
Virginia Commonwealth University

Richmond, Virginia, 23298, United States

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