New heart procedure aims to improve rhythm control in persistent AF patients

NCT ID NCT05922917

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two different ablation techniques using a new, safer method called pulsed-field ablation (PFA) in 300 adults with persistent atrial fibrillation (a type of irregular heartbeat). One group gets standard vein isolation, while the other gets additional targeted burns in the heart. The goal is to see which approach better prevents the return of irregular heartbeats over 12 months.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Ceske Budejovice Hospital

    České Budějovice, 37001, Czechia

  • Institute for Clinical and Experimental Medicine

    Prague, 14037, Czechia

  • University Hospital

    Olomouc, 77900, Czechia