New heart device aims to zap away irregular rhythm
NCT ID NCT05462145
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new device called the Globe Pulsed Field System to treat people with atrial fibrillation (AF), a common heart rhythm problem. The device uses electrical pulses to destroy small areas of heart tissue causing the irregular rhythm. About 549 participants will be followed for 12 months to see if the procedure is safe and effective at preventing AF episodes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Globe Pulsed Field System (a device that uses electrical pulses to ablate heart tissue)
- What this could lead to
- If successful, this could provide a new, safer way to control atrial fibrillation and reduce symptoms without long-term medication.
- What could go wrong
- This is an early-stage study without a control group, so results may not confirm effectiveness. Risks include procedure-related complications like bleeding or heart rhythm issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beaumont Hospital
Royal Oak, Michigan, 48073, United States
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Charité Campus Virchow Clinic
Berlin, Germany
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Doylestown Hospital
Doylestown, Pennsylvania, 18901, United States
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Grandview Medical Center
Birmingham, Alabama, 35243, United States
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Heart and Diabetes Center NRW
Bad Oeynhausen, Germany
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Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Johns Hopkins
Baltimore, Maryland, 21287, United States
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McGill University Health Centre
Montreal, Quebec, H4A 3J1, Canada
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Mercy Hospital
Miami, Florida, 33133, United States
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Motol and Homolka University Hospital
Prague, Czechia
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Mt. Sinai Hospital, Guggenheim Pavilion
New York, New York, 10029, United States
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St. Bernards Medical Center
Jonesboro, Arkansas, 72401, United States
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St. Vincent's Medical Center
Jacksonville, Florida, 32204, United States
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St.Paul's Hospital
Vancouver, British Columbia, V6E 1M7, Canada
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Sutter Health - California Pacific Medical Center
San Francisco, California, 94109, United States
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Texas Cardiac Arrhythmia Research Foundation
Austin, Texas, 78705, United States
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Westpfalz-Klinikum GmbH Kaiserslautern
Kaiserslautern, 67655, Germany
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could a bigger balloon tame the Heart's electrical chaos?
- Can a new heart ablation technique work without x-rays?
- Can a cholesterol drug keep atrial fibrillation at bay after ablation?
- Could a gentle sedation cocktail replace general anesthesia for heart ablation?
- Which ablation method best tames persistent AF? a Head-to-Head trial aims to find out
- Can a new freezing balloon tame a fluttering heart as well as the old one?