Could a bigger balloon tame the Heart's electrical chaos?
NCT ID NCT06053606
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests whether using a larger, expandable balloon during cryoablation for paroxysmal atrial fibrillation better affects the heart's autonomic (automatic) control compared to a standard-size balloon. About 40% of patients show signs of beneficial parasympathetic denervation after cryoablation, and a larger balloon may enhance this effect by sitting closer to key nerve clusters. The study enrolls 100 adults with paroxysmal AF who are scheduled for their first pulmonary vein isolation, and it measures changes in heart rate, time to AF recurrence, and procedure details.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cryoablation using either a standard 28 mm balloon or an expandable 28/31 mm balloon
- What this could lead to
- If the larger balloon enhances beneficial autonomic modulation, it could improve long-term freedom from atrial fibrillation after ablation.
- What could go wrong
- This is an early-stage comparison; the larger balloon may not provide extra benefit, and cryoablation carries risks like heart rhythm disturbances or damage to nearby structures.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Institute of Heart Diseases, Wroclaw Medical University
Wroclaw, Lower Silesian Voivodeship, 50-556, Poland
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new freezing balloon tame a fluttering heart as well as the old one?
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