Zapping the heart back to rhythm: a new device uses pulsed fields to treat atrial fibrillation

NCT ID NCT07714876

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This study tests a device called the Globe Pulsed Field System, which uses short bursts of electric energy to destroy tiny areas of heart tissue that cause abnormal rhythms in people with paroxysmal atrial fibrillation (a type of irregular heartbeat that comes and goes). The trial involves 250 adults who have not responded well to at least one heart rhythm medication. Researchers will track how many patients remain free of atrial fibrillation for 12 months and monitor for serious side effects like stroke or heart damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a device called the Globe Pulsed Field System that uses pulsed electric fields to ablate heart tissue causing abnormal rhythms
What this could lead to
If successful, this device could offer a safer, more precise way to treat atrial fibrillation, reducing the need for long-term medication.
What could go wrong
This is a post-approval study, so the device is already on the market, but long-term effectiveness and rare complications are still being evaluated. Risks include heart damage, stroke, or bleeding.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

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