Could cooling the esophagus make heart ablation safer?

NCT ID NCT06354777

Ongoing Knowledge-focused Sponsor: Heart Rhythm Clinical and Research Solutions, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether actively cooling the esophagus during a common heart procedure (ablation for atrial fibrillation) helps improve outcomes and reduce side effects. Researchers will follow 312 adults with symptomatic atrial fibrillation who are already scheduled for ablation with esophageal cooling. They will track heart rhythm, side effects, and patient-reported symptoms for up to 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: active esophageal cooling (device-based cooling of the esophagus during ablation)
What this could lead to: If successful, this could show that cooling the esophagus during ablation reduces complications and improves recovery for people with atrial fibrillation.
What could go wrong: This is an observational sub-study, not a randomized trial, so results may not prove cause and effect. The findings are limited to short-term follow-up and may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation paroxysmal atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION

Contacts and locations

Locations

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212, United States
Ascension St. Vincent Hospital Indianapolis

Indianapolis, Indiana, 46260, United States
Christ Hospital

Cincinnati, Ohio, 45219, United States
Corewell Health Research Institute

Royal Oak, Michigan, 48067, United States
MultiCare Institute for Research & Innovation

Tacoma, Washington, 98001, United States
Valley Heart Rhythm Specialists

Chandler, Arizona, 85224, United States

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