Could cooling the esophagus make heart ablation safer?
NCT ID NCT06354777
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether actively cooling the esophagus during a common heart procedure (ablation for atrial fibrillation) helps improve outcomes and reduce side effects. Researchers will follow 312 adults with symptomatic atrial fibrillation who are already scheduled for ablation with esophageal cooling. They will track heart rhythm, side effects, and patient-reported symptoms for up to 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
active esophageal cooling (device-based cooling of the esophagus during ablation)
What this could lead to
If successful, this could show that cooling the esophagus during ablation reduces complications and improves recovery for people with atrial fibrillation.
What could go wrong
This is an observational sub-study, not a randomized trial, so results may not prove cause and effect. The findings are limited to short-term follow-up and may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
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Ascension St. Vincent Hospital Indianapolis
Indianapolis, Indiana, 46260, United States
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Christ Hospital
Cincinnati, Ohio, 45219, United States
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Corewell Health Research Institute
Royal Oak, Michigan, 48067, United States
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MultiCare Institute for Research & Innovation
Tacoma, Washington, 98001, United States
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Valley Heart Rhythm Specialists
Chandler, Arizona, 85224, United States