Heart surgery plus ablation: a One-Two punch against stubborn AFib?

NCT ID NCT03546374

Recruiting now Disease control Sponsor: Medtronic Cardiac Surgery Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether using a special radiofrequency ablation device during open-heart surgery can safely stop persistent atrial fibrillation (AFib). About 160 people with long-lasting AFib who need heart surgery for other reasons will receive the ablation. The goal is to see if the procedure can restore normal heart rhythm without major complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Irrigated radiofrequency ablation and cryoablation devices
What this could lead to: If successful, this could provide a safe and effective way to treat persistent atrial fibrillation during open-heart surgery, potentially reducing the need for long-term medication.
What could go wrong: This is a mid-stage study with only 160 participants, and the procedure carries risks like bleeding, stroke, or heart damage. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LONGSTANDING PERSISTENT ATRIAL FIBRILLATION PERSISTENT ATRIAL FIBRILLATION

Contacts and locations

Locations

Adventist Health St. Helena
WITHDRAWN

St. Helena, California, 94574, United States
Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Corewell Health
RECRUITING

Grand Rapids, Michigan, 49503, United States
Hartford Healthcare
COMPLETED

Hartford, Connecticut, 06102, United States
Intermountain Medical Center
COMPLETED

Murray, Utah, 84107, United States
Lankenau Medical Center
COMPLETED

Wynnewood, Pennsylvania, 19096, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
ProMedica Toledo
COMPLETED

Toledo, Ohio, 43606, United States
Sentara Norfolk General Hospital
COMPLETED

Norfolk, Virginia, 23507, United States
St Vincent Heart Center of Indiana
RECRUITING

Indianapolis, Indiana, 46290, United States
St. Joseph Medical Center
WITHDRAWN

Tacoma, Washington, 98405, United States
Stanford Hospitals and Clinic
COMPLETED

Palo Alto, California, 94304, United States
Swedish Medical Center
RECRUITING

Seattle, Washington, 98122, United States
Virginia Mason Heart Institute
RECRUITING

Seattle, Washington, 98101, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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