Heart surgery plus ablation: a One-Two punch against stubborn AFib?
NCT ID NCT03546374
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether using a special radiofrequency ablation device during open-heart surgery can safely stop persistent atrial fibrillation (AFib). About 160 people with long-lasting AFib who need heart surgery for other reasons will receive the ablation. The goal is to see if the procedure can restore normal heart rhythm without major complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Irrigated radiofrequency ablation and cryoablation devices
What this could lead to
If successful, this could provide a safe and effective way to treat persistent atrial fibrillation during open-heart surgery, potentially reducing the need for long-term medication.
What could go wrong
This is a mid-stage study with only 160 participants, and the procedure carries risks like bleeding, stroke, or heart damage. Results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Adventist Health St. Helena
WITHDRAWNSt. Helena, California, 94574, United States
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Allegheny General Hospital
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
Contact Email: •••••@•••••
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Corewell Health
RECRUITINGGrand Rapids, Michigan, 49503, United States
Contact Email: •••••@•••••
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Hartford Healthcare
COMPLETEDHartford, Connecticut, 06102, United States
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Intermountain Medical Center
COMPLETEDMurray, Utah, 84107, United States
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Lankenau Medical Center
COMPLETEDWynnewood, Pennsylvania, 19096, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Email: •••••@•••••
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ProMedica Toledo
COMPLETEDToledo, Ohio, 43606, United States
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Sentara Norfolk General Hospital
COMPLETEDNorfolk, Virginia, 23507, United States
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St Vincent Heart Center of Indiana
RECRUITINGIndianapolis, Indiana, 46290, United States
Contact Email: •••••@•••••
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St. Joseph Medical Center
WITHDRAWNTacoma, Washington, 98405, United States
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Stanford Hospitals and Clinic
COMPLETEDPalo Alto, California, 94304, United States
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Swedish Medical Center
RECRUITINGSeattle, Washington, 98122, United States
Contact Email: •••••@•••••
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Virginia Mason Heart Institute
RECRUITINGSeattle, Washington, 98101, United States
Contact Email: •••••@•••••
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Email: •••••@•••••