New mapping tech could make heart ablation more precise

NCT ID NCT07320560

Recruiting now Disease control Sponsor: German Heart Institute Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests whether a non-invasive global mapping system can help doctors personalize catheter ablation for people with persistent atrial fibrillation (AF). The standard approach isolates the pulmonary veins, but this study adds up to three extra targets based on where the heart shows stable high-rate activity. Researchers will compare outcomes with historical data to see if the personalized approach improves AF termination and reduces recurrence. Forty-five participants will be followed for two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: catheter ablation guided by non-invasive global mapping
What this could lead to: If successful, this approach could make atrial fibrillation ablation more effective by targeting the specific sources of the arrhythmia in each patient.
What could go wrong: This is a small pilot study with only 45 participants, so results may not apply to everyone. The procedure still carries standard risks of catheter ablation, such as bleeding or heart damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION (AF)

Contacts and locations

Locations

Central Lisbon University Hospital Centre (CHULC), Hospital de Santa Marta
NOT_YET_RECRUITING

Lisbon, 1169-024, Portugal
Frankfurt University Heart and Vascular Center
NOT_YET_RECRUITING

Frankfurt am Main, 60598, Germany
German Heart Center of the Charité, Charité University Hospital Berlin
RECRUITING

Berlin, 10117, Germany
Gregorio Marañón General University Hospital
NOT_YET_RECRUITING

Madrid, 28007, Spain
Hospital Clinic, University of Barcelona
NOT_YET_RECRUITING

Barcelona, 08036, Spain

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