New hybrid heart procedure aims to tame stubborn AFib in heart failure patients

NCT ID NCT05411614

Recruiting now Disease control Sponsor: St. George's Hospital, London Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a newer, two-step hybrid ablation procedure works better than standard catheter ablation for people with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. About 120 participants will be randomly assigned to one of the two procedures. The main goal is to see which method better prevents the return of atrial arrhythmias without the need for long-term medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Convergent hybrid ablation (epicardial and endocardial ablation) versus standard catheter ablation
What this could lead to: If successful, this hybrid approach could offer better control of atrial fibrillation in patients with heart failure, potentially improving heart function and quality of life.
What could go wrong: This is a relatively small, early-stage trial (120 participants) comparing two invasive procedures. The hybrid ablation is more complex and may carry higher risks, and it is not yet proven to be superior.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation heart failure left ventricular failure persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL ARRHYTHMIA ATRIAL FIBRILLATION ATRIAL FIBRILLATION, PERSISTENT HEART FAILURE LEFT VENTRICULAR (LV) SYSTOLIC DYSFUNCTION PERSISTENT ATRIAL FIBRILLATION

Contacts and locations

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Locations

Ashford & St Peters Hospital NHS Trust
RECRUITING

Chertsey, United Kingdom
Cromwell Hospital
ACTIVE_NOT_RECRUITING

London, United Kingdom
Epsom General Hospital
RECRUITING

Epsom, United Kingdom
Royal Surrey County Hospital
RECRUITING

London, United Kingdom
St Anthonys Hospital
ACTIVE_NOT_RECRUITING

London, United Kingdom
St Georges University of London
RECRUITING

London, United Kingdom

Contact Email: •••••@•••••
St Georges at Kingston Hospital
RECRUITING

London, United Kingdom

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