New hybrid heart procedure aims to tame stubborn AFib in heart failure patients
NCT ID NCT05411614
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a newer, two-step hybrid ablation procedure works better than standard catheter ablation for people with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. About 120 participants will be randomly assigned to one of the two procedures. The main goal is to see which method better prevents the return of atrial arrhythmias without the need for long-term medication.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Convergent hybrid ablation (epicardial and endocardial ablation) versus standard catheter ablation
What this could lead to
If successful, this hybrid approach could offer better control of atrial fibrillation in patients with heart failure, potentially improving heart function and quality of life.
What could go wrong
This is a relatively small, early-stage trial (120 participants) comparing two invasive procedures. The hybrid ablation is more complex and may carry higher risks, and it is not yet proven to be superior.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ashford & St Peters Hospital NHS Trust
RECRUITINGChertsey, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cromwell Hospital
ACTIVE_NOT_RECRUITINGLondon, United Kingdom
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Epsom General Hospital
RECRUITINGEpsom, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal Surrey County Hospital
RECRUITINGLondon, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St Anthonys Hospital
ACTIVE_NOT_RECRUITINGLondon, United Kingdom
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St Georges University of London
RECRUITINGLondon, United Kingdom
Contact Email: •••••@•••••
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St Georges at Kingston Hospital
RECRUITINGLondon, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••