New Non-Thermal heart ablation shows promise for persistent AF

NCT ID NCT06985901

Recruiting now Disease control Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a new procedure called pulsed-field ablation to treat persistent atrial fibrillation, a common heart rhythm problem. The procedure uses non-thermal energy to isolate the pulmonary veins, aiming to stop abnormal heart signals. Researchers will follow 60 participants for 12 months using an implantable heart monitor to check if the procedure prevents arrhythmia recurrences.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pulsed-field ablation (a non-thermal energy procedure)
What this could lead to: If successful, this could provide a safer, more effective way to treat persistent atrial fibrillation, reducing the need for long-term medication.
What could go wrong: This is a small, early pilot study with only 60 participants, so results may not apply to everyone. The procedure carries risks like bleeding, infection, or heart damage.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERSISTENT ATRIAL FIBRILLATION

Contacts and locations

Locations

CHU de Nice
RECRUITING

Nice, France

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