Centre Hospitalier Universitaire De Nice

This study follows 40 children with Crohn's disease or ulcerative colitis who developed severe psoriasis from anti-TNF drugs and switched to ustekinumab. Researchers will check if their digestive symptoms stay controlled and if their skin improves after 3-6 months. The goal is to…

This study tests whether an ointment called tirbanubulin can effectively treat superficial basal cell carcinoma, a common type of skin cancer. Adults with small, previously untreated lesions on the body (not the face or scalp) apply the ointment once daily for five days. If the l…

This study tests whether artificial intelligence can help doctors personalize rituximab doses for people with membranous nephropathy, an autoimmune kidney disease. About 120 adults with active disease will receive either standard rituximab or AI-guided dosing to keep drug levels …

This trial investigates whether adding the antibiotic rifampicin to standard treatment improves outcomes for people with prosthetic joint infections caused by Cutibacterium acnes bacteria. These infections are hard to treat because the bacteria form a protective biofilm. The stud…

This study is testing a new procedure called pulsed-field ablation to treat persistent atrial fibrillation, a common heart rhythm problem. The procedure uses non-thermal energy to isolate the pulmonary veins, aiming to stop abnormal heart signals. Researchers will follow 60 parti…

This study compares two types of IV fluids—saline and Ringer lactate—in 300 adults with severe diabetic ketoacidosis (DKA) admitted to the ICU. The goal is to see which fluid helps resolve DKA faster within 24 hours. Current guidelines recommend saline, but it may cause side effe…

This study compares giving oral isotretinoin (a strong acne medication) right away versus the usual antibiotics for moderate acne in people with darker skin (Fitzpatrick types IV-VI). The goal is to see if early use of isotretinoin reduces acne-related dark spots better than stan…

This study tests whether taking a daily pill (ritlecitinib) plus twice-weekly narrowband UVB light therapy works better than the pill alone for vitiligo. About 56 adults with non-segmental vitiligo covering 4-60% of their body will take part. The main goal is to see how much skin…

This phase 2 trial tests whether a newer chemotherapy drug called CPX-351 works better than standard chemo for adults aged 50 and older with a hard-to-treat form of acute myeloid leukemia (AML). About 248 people will be randomly assigned to receive either CPX-351 or standard chem…

This study looks at whether people with psoriasis who are doing very well on the drug guselkumab (Tremfya) can safely wait longer than the usual 8 weeks between injections. Researchers will track 100 adults whose doctors have already extended their dosing intervals to see how the…

This study looks at whether giving the drug ravulizumab early, right after standard crisis treatments like plasma exchange or IVIg, can help people with severe myasthenia gravis recover faster in the ICU. About 30 adults with a specific antibody type will be followed for 6 months…

This study looks at how well a new drug called Zilucoplan works for people with myasthenia gravis, a disease that causes muscle weakness. Researchers will track 55 French patients over three months to see if the drug improves muscle strength and daily life, and check for side eff…

This study tests whether early use of the drug bimekizumab can delay or prevent chronic inflammation in people with mild plaque psoriasis. 40 adults with recent-onset or long-standing mild psoriasis will receive either bimekizumab injections or a topical steroid cream. The goal i…

This study looks at whether efgartigimod, a drug that lowers harmful antibodies, can help elderly patients with generalized myasthenia gravis reduce their steroid use. Steroids often cause serious side effects in older adults. The study will follow 50 patients for 12 months to se…

This study tests whether a device that shines light through the toe (photoplethysmography) can quickly detect peripheral artery disease in people with diabetes. The new method measures how long it takes blood to refill the toe after a heartbeat, and researchers compare it to the …

This study tests whether a tablet-based eye-tracking app (eVOG) can detect subtle eye movement problems in people with brain MRI abnormalities (white matter lesions). The goal is to see if these eye movement patterns can help diagnose multiple sclerosis or related conditions. Res…

This study is testing whether a simple voice recording can help detect Alzheimer's disease early. Researchers will analyze speech patterns from 100 volunteers aged 50 and older and compare them to standard Alzheimer's biomarkers. If successful, this could replace painful lumbar p…

This trial compares two standard anesthesia methods—inhaled sevoflurane versus intravenous propofol—during arthroscopic rotator cuff repair. The goal is to see which one gives surgeons a clearer view inside the shoulder joint, which is important for safety and success. About 110 …

This study tests whether a personalized mix of endurance and strength exercises, done at home with video check-ins, can improve mobility and muscle strength in people with mitochondrial myopathy. Fifteen adults with confirmed genetic mutations will follow the program for up to 12…

This study tests whether a virtual reality game can help older adults with mild cognitive disorders improve their inhibitory control—the ability to stop and think before acting. 48 participants will play the game either on a VR headset or a tablet for 20 minutes, twice a week for…

This study tests whether spinal cord stimulation can improve walking in people with ongoing pain after back surgery (Failed Back Surgery Syndrome). Researchers will measure walking patterns in 36 adults before and after 6 months of stimulation. The goal is to see if this treatmen…

This study examines whether the drug omaveloxolone can ease swallowing difficulties in people with Friedreich's ataxia, a rare nerve disease. About 40 French patients who have taken the drug for at least six months will fill out a swallowing questionnaire. The goal is to see if t…

This study tests whether wrapping a stitched finger nerve with MatriDerm, a collagen-elastin matrix normally used for skin healing, improves sensation recovery. Seventy people with traumatic finger nerve cuts will be randomly assigned to receive either standard nerve stitching al…

This study compares same-day discharge versus staying overnight in the hospital after laparoscopic surgery for uncomplicated appendicitis. About 1,400 patients aged 15 to 74 with mild appendicitis will take part. The goal is to see if going home the same day is just as safe and l…

This study tests whether a device that provides gentle stimulation to the muscles and joints (Functional Proprioceptive Stimulation) can help people who recently had a stroke recover their balance and ability to move. The study will include 32 adults who had a stroke within the p…

This study tests whether using a virtual reality headset during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will be offered the headset at different stages of care, from admission to after birth. Researchers will measure how many accept and use it,…

This pilot study tests a 4-week personalized exercise program for people aged 70 and older who are about to have cancer surgery. Participants follow daily exercises at home using a smartphone app. The goal is to see if this approach improves their physical fitness before the oper…

This study looks at whether using a simple quality-of-life questionnaire to decide when to give blood transfusions can reduce the number of transfusions needed for people with advanced myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) who are receiving palliative ca…

This study tests whether remote health education workshops are feasible for adolescents and young adults with cancer. Participants will attend three online sessions designed to help them manage their disease and treatment. The goal is to see if patients stick with the program and…

This study tests whether taking L-tyrosine, a natural supplement, can help lower stress in adults having outpatient hernia surgery. About 150 participants will receive either L-tyrosine or a placebo before surgery, and their anxiety levels will be measured. The goal is to find a …

This study looks at whether a common surgery for pelvic organ prolapse can be performed without an overnight hospital stay. About 80 women with symptomatic prolapse will receive laparoscopic surgery with or without robotic help. The goal is to see if same-day discharge is safe an…

This study tests whether amiloride, a drug used for high blood pressure, can reduce the number of migraine aura attacks. About 40 adults with migraine with aura will take amiloride or a placebo for several weeks, then switch. The goal is to see if amiloride can prevent the visual…

This study compares two new pain management methods—methoxyflurane (an inhaled painkiller) and a virtual reality headset—against standard care for people with a dislocated shoulder. The goal is to see if these approaches reduce the need for strong sedative drugs during the proced…

This study tests a new way to perform psoas tenotomy, a surgery that cuts a tendon to relieve hip pain after hip replacement. Instead of using a camera or X-ray, the surgeon uses ultrasound to guide the cut, which may be simpler and less invasive. The study will enroll 15 adults …

This study explores whether a substance called thromboxane A2, which is involved in blood clotting and fat metabolism, also plays a role in osteoarthritis. Researchers will measure thromboxane levels in blood and joint fluid from 20 people with knee osteoarthritis and look for a …

This study investigates how chronic lymphocytic leukemia (CLL) cells change their energy use when they are in the lymph node environment, which may help them resist standard treatments. Researchers are building a lab model using patient leukemia cells and normal lymph node cells …

This study looks at two types of fat tissue in people with knee osteoarthritis: one inside the knee joint (Hoffa's fat pad) and one inside the thigh muscle. Researchers want to see if these fat deposits are different in size, fat content, and scar tissue. The goal is to better un…

This study tests whether an artificial intelligence algorithm can predict survival and complications in people who have had a cardiorespiratory arrest and been revived. Researchers will analyze hospital records from 300 to 500 patients treated in intensive care units in France be…

This study looks at children under 15 with neurofibromatosis type 2 (NF2), a rare genetic condition that causes nerve tumors. Researchers want to see if skin and mouth lesions can help diagnose NF2 earlier than current methods, which rely on hearing, nerve, and eye symptoms. By e…

This study looks at skin problems that appear during a COVID-19 infection, with a special focus on chilblains (painful red or purple bumps on fingers or toes). Researchers want to understand why these skin changes happen—whether from the virus itself, tiny blood clots, or inflamm…

This study investigates whether older adults with age-related hearing loss (presbycusis) can still hear and enjoy the sound of a crunchy biscuit while eating. Researchers will compare a crunchy biscuit with a soft one in 100 seniors aged 65 and older, asking them if they hear the…

This study follows a large group of people with HIV over many years to track their health, treatments, and any complications. Researchers will collect medical data during regular clinic visits to better understand how the disease and its treatments affect patients over time. The …

This study looks at whether machine learning can predict if a patient in intensive care will succeed in a spontaneous breathing test—a key step before removing a ventilator. Researchers will analyze biosignals like heart rate and breathing patterns from 500 patients' medical reco…

This study investigates why some men have difficulty using the pump of their inflatable penile prosthesis after surgery, leading to dissatisfaction. Researchers will look at factors like age, weight, pump type, and whether patients saw a demonstration before surgery. The goal is …

This study gathers information from memory clinics across France to track how many people have Alzheimer's disease, how it progresses, and what factors affect diagnosis and care. Researchers will analyze anonymous medical records from over 500 centers to spot trends in health and…

This study looks at how the location of brain-stimulating electrodes affects pain relief in adults with long-term nerve pain that hasn't improved with other treatments. Researchers will use brain scans to see which areas are activated and how that relates to pain reduction. The g…

This study is analyzing inflammatory markers in the blood and spinal fluid of 300 people who are being checked for multiple sclerosis (MS). The goal is to see if certain markers can help doctors tell MS apart from other autoimmune diseases that affect the brain and spinal cord. R…

This study looks for specific signs of long COVID in the brain and blood. Researchers will compare people with and without long COVID symptoms using brain scans and blood tests. The goal is to find objective markers that could help doctors diagnose long COVID more reliably.

This study is collecting blood, urine, and kidney tissue samples from 144 children and adults with a kidney condition called nephrotic syndrome. The goal is to build a large database and sample collection to study how the immune system and kidney cells interact. Researchers hope …

This study is following 1,000 people in the Alpes-Maritimes region of France to see how many were infected with the coronavirus during the deconfinement period. Researchers are using blood tests to measure immune responses and will also look at how air pollution might affect the …

This study looks at 150 hospital patients who get a bloodstream infection from a long-term arm catheter (PICC or Midline). It checks whether having a superficial (surface) vein clot along with the infection leads to worse outcomes, like the infection coming back or spreading. The…

This study looks at people with HIV who are 75 or older and take at least five medications regularly. Researchers want to understand how this 'polypharmacy' affects healthy aging and quality of life. They will interview participants and review their medical records to count medic…

This study looks at early changes in mitochondria (the energy centers of cells) and metabolic markers in blood cells of people with Alzheimer's or related dementias. Researchers will compare these measures between those with and without Alzheimer's to find clues about how the dis…

This study looks at blood cells from people with chronic myelomonocytic leukemia (CMML) to learn more about how the disease works. Researchers will study specific immune cells, including monocytes and immature granulocytes, to understand why they don't develop normally. The goal …

This study follows 50 adults with generalized myasthenia gravis who are taking Rozanolixizumab. Researchers want to see how the drug affects symptoms like fatigue and muscle weakness from the patient's own point of view. Participants will fill out a special questionnaire over 9 m…

This study is gathering information from 400 adults in France diagnosed with membranous nephropathy, a rare kidney condition. Researchers will track how the disease progresses over one year, looking at remission rates and possible environmental or genetic risk factors. The goal i…

This study will collect fluid samples from 200 patients undergoing digestive surgery to examine how innate immune cells behave during inflammation. Researchers will analyze the fluid and cells to identify inflammatory markers and cell types. The goal is to better understand immun…

This study looks at whether certain bacteria or viruses in the bladder might be linked to bladder cancer. Researchers will compare the germs found in cancerous bladder tissue with those in healthy tissue from the same person. The goal is to see if there are differences that could…

This study looks at whether paracetamol, a common pain and fever medicine, can cause a significant drop in blood pressure in intensive care patients. Researchers will monitor 200 adults in the ICU who receive paracetamol either by IV or by mouth. The goal is to find out how often…

This study is testing whether a continuous glucose monitor (CGM) designed for diabetes can work in intensive care patients with septic shock. Currently, nurses must prick patients' fingers every 2 hours to check blood sugar, which is painful and disruptive. The CGM uses a small s…

This study looks at whether the heart's pumping ability plays a role in why some patients fail to come off a mechanical ventilator. Researchers will use ultrasound to check heart and lung function before and during a breathing test in 250 intensive care patients. The goal is to b…

This study compares two groups of healthy adults over 55: those who have exercised regularly for 30 years and those who have not. Researchers will test blood and physical function to see how lifelong activity affects T cell metabolism and overall vitality. The goal is to understa…

This study aims to understand why many patients have poor sleep after scheduled surgery. Researchers will give questionnaires to 1,000 adults undergoing general anesthesia to measure sleep quality and daytime drowsiness. The goal is to identify factors that disrupt sleep, such as…

This study looks at whether getting a flu shot in the morning or evening makes a difference for people with chronic kidney disease. Researchers will measure antibody levels four weeks after vaccination to see which time works better. The study involves 735 adults with advanced ki…

This pilot study tests whether a special wire can safely measure blood flow in the brain's smallest blood vessels right after a stroke clot is removed. The goal is to understand why some patients still have disability even when the main artery is reopened. Fifteen adults who had …

This study aims to find out how many adults with type 2 diabetes experience severe diabetes-related distress—a feeling of being overwhelmed by the demands of managing the disease. Researchers at a French hospital will ask 246 participants to fill out questionnaires about their em…

This study looks at how certain natural chemicals in the body affect blood vessel health in people with pseudoxanthoma elasticum (PXE), a rare genetic disease that causes calcium buildup in tissues. Researchers will measure levels of these chemicals in 45 adults with PXE to bette…

This study uses high-resolution ultrasound to look at nerves in people with Friedreich ataxia, a rare inherited disease that damages the nervous system and heart. Researchers want to see if nerve size and blood flow are different in these patients. The goal is to find new ways to…

This study is testing whether a simple finger-prick blood test for lactate, done in the ambulance, can help predict which patients with serious injuries from accidents or falls will have poor outcomes. Researchers will enroll 550 adults with potentially severe trauma and measure …

This study looks at how GLP-1 medications (like Ozempic) affect fat tissue in people with severe obesity who are scheduled for weight-loss surgery. Researchers will compare fat samples from 40 patients—half taking a GLP-1 drug and half not—to see changes in oxytocin and other mar…

This study looks at sleep quality in people who had cancer between ages 15 and 24. Researchers will ask 400 survivors to fill out a detailed online questionnaire about their sleep, pain, and daily life. The goal is to find out how many have moderate to severe insomnia and what fa…

This study looks at a rare but often deadly infection caused by Bacillus cereus bacteria in premature newborns. Researchers will analyze the DNA of 40 bacterial samples from infected babies in French hospitals to see which genetic features make some strains more dangerous. The go…

This study looks at 40 newborns with isolated rectal bleeding to see how many have a cow's milk protein allergy versus a temporary condition called transient neonatal colitis. By removing and then reintroducing cow's milk from the diet, doctors can confirm an allergy if bleeding …

This study looks at people with radiologically isolated syndrome (RIS) — a pre-symptomatic stage of multiple sclerosis — and compares them to MS patients with normal neurological exams. Researchers will use digital tools, MRI scans, and biological tests to find better ways to tra…

This study is investigating why some melanomas stop responding to immunotherapy. Researchers will take biopsies from 20 patients with advanced melanoma before and after treatment to see how tumor metabolism changes. The goal is to understand resistance mechanisms and find new way…

This study surveys 160 French dentists and dental trainees to understand how 'attentional tunneling' (focusing too much on one detail) can cause errors in dental care. Researchers will use questionnaires to measure knowledge of this bias and identify risk factors. The goal is to …

This study examines whether an HPV education program called e-Bug, used in one middle school in France, is linked to higher parental consent and vaccination rates. Researchers compared anonymized vaccination data from that school with regional averages. No students were directly …

This study checks if people with lymphedema have higher levels of lipoprotein(a), a substance linked to heart disease. Researchers will test blood from 100 adults with lymphedema to see how common high LP(a) is. The goal is to learn if lymphedema patients need extra heart risk mo…

This study looks at why some older adults improve more with exercise than others. Researchers will track 900 people aged 60 and older, measuring muscle power, blood markers, and physical function before and after a 12-week activity program. The goal is to find biological and phys…

This study looks at how liver cirrhosis and liver transplantation affect hardening of the arteries (arterial calcification). Researchers will measure a substance called pyrophosphate in the blood and urine of 95 people waiting for a liver transplant. They want to see if the trans…

This study looks at how different types of hormone therapy (like birth control pills) affect knee looseness in healthy women aged 18-40. Researchers will measure knee movement using a special device. The goal is to understand why women have a higher risk of ACL injuries and wheth…

This study interviews 10 migrant and socially vulnerable people who visit the Doctors of the World center in Nice. The goal is to learn about their health needs and what might help them take part in group health activities. Researchers hope to find ways to overcome barriers like …