Centre Hospitalier Universitaire De Nice

This study compares a new drug, CPX-351, to standard chemotherapy in 248 adults aged 50 and older with newly diagnosed acute myeloid leukemia (AML) that is at intermediate or high risk. The goal is to see if CPX-351 leads to deeper remission with less remaining cancer cells after…

This study tests whether the drug bimekizumab, given early in plaque psoriasis, can delay or prevent the disease from becoming a long-term condition. 40 adults with mild psoriasis (less than 6 months or more than 2 years) will receive either bimekizumab injections or a topical st…

This study looks at how well a new drug called Zilucoplan works for people with myasthenia gravis, a disease that causes muscle weakness. Researchers will track 55 French patients over three months to see if the drug improves muscle strength and daily life, and check for side eff…

This study tests whether artificial intelligence can help doctors personalize the dose of the drug rituximab for people with membranous nephropathy, an autoimmune kidney disease. About 120 adults with active disease will receive either standard rituximab or a dose adjusted by an …

This study looks at whether giving the drug ravulizumab early, after standard treatments, can help people with a life-threatening myasthenia gravis crisis recover faster in the ICU. About 30 adults in France will be observed for 6 months. The goal is to see if it reduces time on …

This study compares same-day discharge versus standard overnight hospital stay for people with uncomplicated appendicitis who have laparoscopic surgery. About 1,400 participants aged 15-74 will be randomly assigned to either go home the same day or stay in the hospital. The goal …

This study compares two new pain management methods—methoxyflurane (an inhaled painkiller) and a virtual reality headset—against standard care for people with a dislocated shoulder. The goal is to see if these approaches reduce the need for strong sedative drugs during the proced…

This study tests whether amiloride, a drug usually used for high blood pressure, can reduce the number of migraine aura attacks (like seeing flashing lights or zigzag lines). About 40 adults with migraine with aura will take either amiloride or a placebo for a few months, then sw…

This study looks at whether omaveloxolone, a drug recently approved in France, can ease swallowing difficulties in people with Friedreich's ataxia. About 40 patients will fill out a swallowing questionnaire before starting the drug and again after six months. The goal is to see i…

This study tests whether using virtual reality (VR) headsets during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will be offered VR from admission through recovery. The goal is to see if this approach is practical and improves the birth experience.

This study tests whether wrapping a stitched finger nerve with a special skin scaffold (MatriDerm) helps improve sensation recovery. About 70 people with cut nerves in their fingers or palm will be randomly assigned to get either standard nerve stitching alone or stitching plus t…

This study looks at whether adding a physical activity education program to regular exercise helps people with mild memory or thinking problems more than exercise alone. About 34 participants will be followed for 6 months to see changes in activity level, thinking skills, and qua…

This study tests if a special wire can safely measure blood flow in the tiny blood vessels of the brain right after a stroke clot is removed. Even when the main artery is cleared, many patients still have disabilities, possibly because the smallest vessels aren't getting enough b…

This study checks if a classroom program called e-Bug, which teaches students about HPV, leads to more parents agreeing to the HPV vaccine. Researchers compared vaccination rates at one middle school that used the program with the rest of the region. No students were enrolled or …

This study looks at whether online health education workshops are practical and helpful for teenagers and young adults (ages 15-25) who have cancer. About 48 participants from across France will take part in three digital sessions designed to teach skills for managing daily life …

This study looks at how GLP-1 medications (like Ozempic) change fat tissue in people having weight-loss surgery. Researchers will measure oxytocin levels and fat quality in 40 patients, comparing those who took GLP-1 drugs for at least 3 months to those who did not. The goal is t…

This study is testing whether a quick, painless finger-prick test measuring lactate levels can help predict how serious a person's injuries are after a major accident, like a car crash or a high fall. The goal is to give emergency responders a simple, objective tool to decide whi…

This study looks at how liver cirrhosis and liver transplants affect artery calcification (hardening of the arteries). Researchers will measure changes in artery calcification and a substance called pyrophosphate in 95 adults before and after liver transplantation. The goal is to…

This study looks at 150 people who either have radiologically isolated syndrome (RIS) — early brain changes that may lead to multiple sclerosis (MS) — or have MS but no physical symptoms. Researchers will use digital tools, MRI scans, and blood tests to find better ways to track …

This study looks at how certain natural chemicals in the body affect blood vessel health in people with pseudoxanthoma elasticum (PXE), a rare genetic disease that causes calcium buildup in tissues. Researchers will measure levels of these chemicals in 45 adults with PXE to bette…

This study looks at whether getting a flu shot in the morning or evening makes a difference for people with chronic kidney disease. Researchers will measure antibody levels four weeks after vaccination to see which timing leads to a stronger immune response. The study involves 73…