Centre Hospitalier Universitaire De Nice

This study tests dalbavancin, a long-acting antibiotic given as a few shots over two months, for infections that occur after hip or knee replacement surgery. The standard treatment requires 12 weeks of daily antibiotics, which can be hard to tolerate and complete. The trial inclu…

This phase 2 trial tests deucravacitinib, a daily pill that targets the immune system, to see if it can stop vitiligo from spreading and help skin regain its color. About 128 adults with non-segmental vitiligo will take the drug or a placebo for 24 weeks, then some will also rece…

This study compares a drug-coated balloon to a standard balloon for treating narrowed blood vessels in dialysis patients. The drug-coated balloon releases paclitaxel to help prevent the vessel from narrowing again. The goal is to see if it keeps the access working longer and redu…

This study tests a new surgical method called RADAR for creating blood vessel connections needed for dialysis in 200 people with end-stage kidney disease. The goal is to see if this technique leads to fewer blockages and better long-term function compared to the standard approach…

This pilot study is testing whether robot-assisted prostate removal for localized prostate cancer can be safely performed as outpatient surgery, meaning patients go home the same day. Twenty men will be enrolled and followed for one month to see if they can avoid a conventional h…

This pilot study is testing whether a 24-week program of adapted physical activity, combined with diet advice, can reduce liver fat in 115 adults with non-alcoholic fatty liver disease (NAFLD). Participants will follow personalized exercise and diet plans, and researchers will me…

This study follows 20 adults with spinal muscular atrophy (SMA) type II who are already taking SPINRAZA. Researchers will measure motor function using a 32-point scale over 27 months to see if the drug helps maintain or improve movement. The goal is to better understand how SPINR…

This study tests whether a special 1064nm laser can treat melasma and prevent it from returning. Thirty adults with moderate to severe melasma will receive laser on one side of their face every two weeks for 12 weeks, while using sunscreen and a depigmenting cream on their whole …

This study planned to compare a newer blood test (presepsine) with a standard one (lactate) for diagnosing severe sepsis and septic shock in emergency department patients. The goal was to see if presepsine could detect these life-threatening infections more accurately. However, t…

This study compares lung ultrasound (LUS) with chest X-ray for diagnosing community-acquired pneumonia in emergency room patients. Researchers will enroll 47 adults with suspected pneumonia to see if LUS is as accurate as X-ray. If LUS proves reliable, it could offer a faster, ra…

This study tests a special ultrasound technique called Superb Microvascular Imaging (SMI) to see blood flow inside eye tumors. The goal is to help doctors tell benign from malignant tumors more accurately, especially when standard tests are unclear. Twenty-two adults with untreat…

This study planned to test whether automated music therapy could help manage agitation and sleep problems in people with severe Alzheimer's living in nursing homes. An actigraph would detect sleep issues and trigger music sessions automatically. The trial was withdrawn before any…

This study looks at whether special video games (serious games) that combine physical and mental exercises are a good value for managing Alzheimer's disease. About 136 people with mild to moderate Alzheimer's will either play these games with a therapist or receive usual care. Re…

This study tests whether playing relaxing music during dental treatment with nitrous oxide (laughing gas) helps children aged 4 to 12 feel more comfortable and reduces the need for general anesthesia. About 177 children will have two dental sessions—one with music and one without…

This study tests whether wearing a virtual reality headset during chest drainage can reduce anxiety and pain. About 38 adults with pneumothorax or pleural effusion will either get standard care or use a VR headset during the procedure. Researchers will measure pain and anxiety us…

This pilot study explores whether fine motor hand exercises can help improve swallowing problems in older adults who recently had a stroke. Researchers believe that activating the hand and mouth areas of the brain together may boost recovery. The study involves 30 participants an…

This study tests if a biceps tendon cutting procedure (tenotomy) done in the doctor's office with a tiny camera and local anesthesia works as well as the same surgery in an operating room. 14 adults with shoulder pain from biceps or rotator cuff problems will be enrolled. The mai…

This study tests a two-phase plant-based treatment for women who get frequent bladder infections (at least 4 per year). The treatment uses antibacterial essential oils during an infection and medicinal plants long-term to prevent future episodes. The goal is to see if this approa…

This study tests whether a gentle electrical current applied to the scalp (tDCS) can reduce obsessive-compulsive disorder (OCD) symptoms in people who haven't gotten better with standard therapy. 43 adults with severe, long-lasting OCD will receive either real or fake stimulation…

This study tests whether injecting botulinum toxin into the thumb joint can reduce pain and improve function in people with thumb osteoarthritis (rhizarthrosis). Sixty adults with moderate to severe pain who have not responded to standard painkillers will receive either botulinum…

This study tests whether a gentle electrical brain stimulation technique called tDCS, combined with cognitive training on a tablet, can reduce apathy in older adults with mild cognitive impairment. Apathy is a lack of motivation and interest that can affect daily life. The trial …

This study looks at HIV patients over 40 (or those on HIV therapy for over 10 years) who switched to either a three-drug or a two-drug antiretroviral regimen. Researchers will measure markers of inflammation in the blood and track how many patients develop other health conditions…

This study was designed to see if the drug raltegravir could reduce hidden HIV in immune cells (lymphocytes and monocytes) in people with HIV who already had undetectable virus levels. It planned to enroll adults aged 18-60 with well-controlled HIV. However, the study was withdra…

This was a planned French study to collect information on chronic myeloid leukemia (CML) in young adults aged 18 to 30 who were treated with tyrosine kinase inhibitors. The goal was to describe their diagnosis, treatment choices, side effects, and quality of life. However, the st…

This pilot study aimed to understand how psychological factors like personality and motivation influence whether older adults (55+) use a smartphone app to track physical activity. Participants would have used the WeWard app for 12 weeks while researchers monitored steps, walking…

This study aimed to measure brain blood flow and oxygen levels in critically ill patients with septic shock, and to see how common treatments like fluids and blood transfusions affect them. The researchers planned to use ultrasound to monitor blood flow in the brain. However, the…

This study follows 90 people who survived severe COVID-19 pneumonia and needed intensive care. Researchers will check their physical health, mental health, and quality of life at 3 months, 6 months, 1 year, and 5 years after leaving the ICU. The goal is to better understand the l…

This study looks at whether low levels of pyrophosphate, a natural substance that prevents mineral buildup, can predict artery hardening in people with moderate chronic kidney disease. Researchers will measure pyrophosphate in blood samples from 242 patients and track artery chan…

This study aims to find out how many people with high blood tryptase levels have a genetic condition called hereditary hyper-alpha-tryptasemia. Researchers will test 100 patients who have had allergic reactions and high tryptase levels. The results may help doctors better manage …

This study looks at blood inflammation in people with moderate to severe atopic dermatitis (eczema). Researchers will take blood samples before and after 3 months of treatment to see how immune signals change. The goal is to better understand the immune response in different pati…

This study planned to see if a special care plan for extremely premature babies (born before 28 weeks or weighing under 1000 grams) could be successfully carried out in the first hour after birth. The goal was to stabilize these fragile newborns quickly to prevent complications l…

This study looks at whether artificial intelligence (AI) can match a dermatologist's diagnosis when a general practitioner sends in photos and questions about a patient's skin condition. Researchers will compare the AI's diagnosis to the dermatologist's for about 1000 adults. The…

This study surveys 500 corresponding authors from top medical journals to understand their attitudes, perceptions, and self-reported use of artificial intelligence in research. Participants complete an anonymous online questionnaire about AI tools for idea generation, literature …

This study tracks how long the flu virus stays in the upper airways of 18 hospitalized adults who are taking oseltamivir (Tamiflu). The goal is to see if antiviral treatment can safely shorten the time patients need to stay in isolation, freeing up hospital rooms during flu seaso…

This study looks at how brain tumors change the way different parts of the brain connect and communicate. Researchers will use brain scans and electrical recordings from 30 adults scheduled for tumor removal surgery. The goal is to better understand brain plasticity and improve f…

This study aims to find blood biomarkers that predict recurrent urinary tract infections (UTIs) in women. Researchers will collect blood, urine, fecal, and vaginal samples from 109 healthy women aged 18–28, comparing those with a history of single versus recurrent cystitis. The g…

This study is working to create better tools for measuring muscle function in people with facioscapulohumeral muscular dystrophy (FSHD). Researchers will follow 100 adults with FSHD for up to 24 months, testing new ways to track disease progression. The goal is to make future cli…

This study planned to test newborn babies' hair for traces of drugs their mothers took during pregnancy. Hair can show drug exposure over months, unlike blood or urine tests. The goal was to better understand how these substances get into babies' hair. However, the study was with…

This study aimed to see if diabetic patients have slower stomach emptying than non-diabetic patients before scheduled surgery, using a simple ultrasound. It was designed to compare stomach contents after fasting in both groups. However, the study was withdrawn before enrolling an…

This study looks at how often a common heart side effect (first-degree atrioventricular block) occurs when verapamil is used at high doses to prevent cluster headaches. Researchers will monitor 60 patients starting or already on verapamil, using ECGs and blood tests. The goal is …

This study is testing a new, comfortable headset that reads brain signals to help people with ALS type on a virtual keyboard. The goal is to improve the device so it can be used in daily life. Five people with ALS will try the headset, and researchers will measure how easy it is …

This study aims to find better ways to measure disease progression in people with advanced facioscapulohumeral muscular dystrophy (FSHD) who use wheelchairs. Researchers will test various muscle strength and function tests over two years in 30 adults. The goal is to develop relia…