Exercise over pills: new study tests if moving more can shrink fatty liver

NCT ID NCT04835831

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study is testing whether a 24-week program of adapted physical activity, combined with diet advice, can reduce liver fat in 115 adults with non-alcoholic fatty liver disease (NAFLD). Participants will follow personalized exercise and diet plans, and researchers will measure changes in liver fat, weight, and muscle function. The goal is to see if lifestyle changes alone can help control this common liver condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

adapted physical activity program plus dietetic advice

What this could lead to

If successful, this could show that a structured exercise program helps reduce liver fat in people with fatty liver disease, offering a drug-free management option.

What could go wrong

This is a small pilot study with no control group, so results may not be definitive. Long-term adherence and lasting effects are uncertain.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHU de Nice

    Nice, France, 06000, France

  • Ch de Perpignan

    Perpignan, France, 66046, France