Can a promising NAFLD drug safely mix with other medicines? a trial seeks answers
NCT ID NCT07726368
First seen Jul 24, 2026 · Last updated Jul 29, 2026 · Updated 2 times
Summary
This trial investigates whether ECC4703, a potential new treatment for non-alcoholic fatty liver disease (NAFLD), changes how the body processes two other drugs: sulfasalazine and pitavastatin. Healthy adults aged 18 to 65 will take these drugs alone and then with ECC4703 to measure any differences in drug levels. The goal is to understand possible drug interactions early, ensuring safety for future patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ECC4703, sulfasalazine, and pitavastatin
- What this could lead to
- If successful, this trial could help determine safe dosing of ECC4703 with common medications, supporting its development as a treatment for non-alcoholic fatty liver disease.
- What could go wrong
- This is an early-phase drug interaction study in healthy volunteers, not patients. Results may not predict real-world effects in people with NAFLD, and ECC4703 could still fail in later trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female between the ages of 18 and 65 years, inclusive, at the time of Screening. * Are healthy and in the opinion of the Investigator have an acceptable medical history (free from significant cardiac, pulmonary, gastrointestinal, hepatic, renal, haematological, neurological, infective, or psychiatric diseases as determined by medical history over the past 5 years, physical examination, vital signs, 12-lead ECG, and clinical laboratory tests). * Has not consumed and agrees to abstain from taking any prescription drugs or non-prescription drugs for 7 days or 5 half-lives (whichever is longer) prior to first dose of trial treatment and continuing through end of the Treatment Period. Exclusion Criteria: * Has a history of significant renal, hepatic, cardiovascular, psychiatric, neoplastic, thyroid disease/abnormality or other disease which, in the opinion of the Investigator, represents a safety risk for taking part in the trial. * Has a history of sensitivity to any of the trial treatments (and/or their excipients), or severe drug or other allergy * Has a history of drug abuse within the previous 2 years, or a positive drug screen at Screening and/or Day -1. * Regular consumption of more than 10 standard alcoholic drinks/week and/or more than 4 standard alcoholic drinks on any one day * Has a history or current diagnosis of a significant psychiatric disorder that would, in the opinion of the Investigator, affect the participant's ability to comply with the trial requirements. * Has a personal or family history of hereditary muscular disorders, previous statin-induced myopathy/rhabdomyolysis, or unexplained repeated or severe muscle pain. * Has a history of any unexplained chronic skin rash or autoimmune skin diseases. * Has a personal or family history of Stevens-Johnson syndrome (SJS), or other severe drug-induced skin reactions. * History of surgery or hospitalisation within 3 months prior to screening, or surgery planned during the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Nucleus Network Pty Ltd
Melbourne, Victoria, 3004, Australia
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