Centre Hospitalier Universitaire De Nice

This phase 2 trial tests whether dapagliflozin, a drug used for diabetes and heart failure, can reduce harmful antibodies and prevent relapses in people with membranous nephropathy, an autoimmune kidney disease. The study enrolls 20 adults who have had a recent rise in anti-PLA2R…

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard narrowband UVB light treatment can help restore skin color in people with vitiligo. Five adults with non-segmental vitiligo will receive UVB twice a week for 24 …

This study tests a set of safety measures to lower infections from external ventricular drains (EVDs) in 248 ICU patients. The bundle includes updated care protocols, staff training, and reminder signs. The goal is to cut the current 22% infection rate by improving hygiene and ha…

This study compares two ways of giving the drug tocilizumab to people with rheumatoid arthritis that is under control. One method uses a fixed dose for everyone, while the other adjusts the dose based on weight. The goal is to see if the simpler fixed-dose method works just as we…

This study tests whether methotrexate, a drug used for other types of arthritis, can slow joint damage in people with painful hand osteoarthritis that hasn't gotten better with standard treatments. About 170 adults with erosive hand osteoarthritis will receive either methotrexate…

This study tests a daily pill called upadacitinib for people with severe forms of lichen planus, a skin disease causing painful mouth sores or hair loss. About 56 adults will receive either the drug or a placebo for 16 weeks to see if it reduces symptoms. The goal is to control t…

This study tests whether empagliflozin, a diabetes medicine, can reduce protein leakage in urine and help protect the kidneys in people with very advanced chronic kidney disease (eGFR between 10 and 20). About 34 adults with type 2 diabetes will take either empagliflozin or a pla…

This pilot study aims to develop a new digital PCR technique to more accurately diagnose mitochondrial diseases. Researchers will test the method on blood, urine, saliva, and muscle fiber samples from 4 patients. If validated, the technique could be faster and cheaper than curren…

This study will test a 4D virtual simulator called Modjaw to see if it helps doctors diagnose temporomandibular joint (TMJ) disorders more accurately. About 20 adults with suspected disc displacement will use the device, and the results will be compared to MRI scans. The goal is …

This study tests whether a personalized virtual reality program that uses sights, sounds, smells, and tastes can reduce apathy in older adults with cognitive impairment living in nursing homes. Ten participants will attend weekly sessions for six weeks, reliving meaningful memori…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can help people over 70 recover swallowing after a stroke. Twenty participants will receive either active or sham stimulation alongside standard speech therapy for three weeks. Researchers wi…

This study investigates sexual and urinary problems in people with generalized myasthenia gravis, an autoimmune disease that causes muscle weakness. While visible symptoms like droopy eyelids are well-known, issues like sexual dysfunction and bladder problems are often ignored. R…

This study investigates how a person's total environment—including lifestyle habits like diet and exercise, social factors, and exposure to pollutants—affects the aging process. Researchers will follow 400 volunteers aged 55 and older from southeastern France, collecting blood sa…

This observational study will check vitamin C levels in 40 people with osteoporosis, comparing those who have had a spine fracture to those who haven't. The goal is to see if lower vitamin C is more common in the fracture group. No treatment is given; the study simply measures an…

This study will observe 10 adults with acute myeloid leukemia who are receiving the drug gilteritinib after a stem cell transplant. Researchers want to understand how gilteritinib affects the behavior, metabolism, and function of immune cells like T-cells and monocytes. The goal …

This study compares three antibiotic combinations given to adults with suspected infections of joint or bone implants (like hip or knee replacements). The goal is to see how each antibiotic strategy changes the diversity of bacteria in the gut and whether it leads to more antibio…

This study looks at how personal habits, beliefs, social surroundings, and environment work together to affect health and independence in people aged 55 and older. Participants fill out questionnaires and do simple tests to measure things like daily living skills, physical activi…

This study aims to measure pressure inside the belly and in the belly muscles during surgery to fix a type of hernia called an incisional hernia. Ten adults with a medium-sized hernia will have pressure readings taken before, during, and after their operation. The goal is to bett…

This study looks back at records of over 1,000 new hospital workers in Nice, France, who were tested for latent (hidden) tuberculosis infection as part of their hiring process. The goal is to see how many test positive, what factors increase the risk, and whether the screening le…

This study tests different exercise programs to see which one helps older adults stay physically active over the long term. Six hundred people aged 60 and older will be assigned to one of four groups, each with a different approach to exercise. The goal is to find strategies that…

This study tests whether a co-designed exercise program helps seniors stay physically active. 60 participants aged 60+ will choose their own activities from a menu and attend two sessions per week for 12 weeks. Researchers will measure adherence during the program and physical ac…

This study looks at why some people with acute lymphoblastic leukemia (ALL) have severe allergic reactions to the drug asparaginase. Researchers will collect blood cells from 20 patients and test them in the lab to see if certain immune cells (T cells) become overactive. The goal…

This study tests a drug called GC7 in 20 people who have had a cardiac arrest and been revived. The goal is to see if GC7 can reduce cell damage caused by the sudden return of blood and oxygen. Researchers will measure stress levels in blood cells and look for signs of improved r…

This study looks at the immune system of 120 women aged 18-40 with chronic pelvic pain that hasn't improved with hormone treatment. Researchers will measure specific immune markers in the blood to see if there is a unique pattern linked to the pain. The goal is to better understa…

This study aims to understand how working night shifts in busy hospital settings like intensive care and emergency rooms affects what and when healthcare workers eat. Researchers will ask 245 adults who work night shifts in healthcare or other jobs to fill out an online questionn…

This study uses computer simulations to compare custom-made implants with standard miniplates for fixing the upper jaw after surgery. Researchers will analyze stress on the implants and bone, as well as jaw movement, in two different surgical scenarios. The goal is to provide ins…

This study looks at how two types of peripheral neuropathy—hereditary and inflammatory—affect daily life and well-being. Researchers will ask 60 adults to fill out questionnaires about their functioning, independence, and quality of life. No treatments are given; the goal is to b…

This study will test whether robotic surgery can be used for emergency abdominal operations, such as for severe gallbladder infections or bowel blockages. The goal is to see if it's feasible and if it can lower complication rates and shorten hospital stays compared to traditional…