Can a blood pressure cuff shield the brain after a severe stroke?
NCT ID NCT07761520
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial tests whether a simple, non-invasive technique called remote ischemic preconditioning (RIPC) can reduce brain damage after an aneurysmal subarachnoid hemorrhage, a severe type of stroke. The procedure involves briefly inflating a blood pressure cuff on the leg to restrict blood flow, repeated every two days for about a week. Researchers will compare this to a sham procedure in 140 adult patients, measuring neurological disability at 3 months and longer-term outcomes at 12 months. If it works, RIPC could offer a low-cost way to improve recovery after this serious condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Remote ischemic preconditioning (RIPC) - a procedure using a blood pressure cuff to briefly restrict blood flow to the leg, repeated every two days from day 2 to day 10 after hemorrhage.
- What this could lead to
- If effective, RIPC could become a simple, low-cost, widely accessible method to reduce disability and improve recovery after aneurysmal subarachnoid hemorrhage.
- What could go wrong
- The trial is early and the procedure's benefit in this condition is uncertain. It may not improve outcomes, and there is a small risk of limb discomfort or injury from the cuff.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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