Brain bleed breakthrough? new drug could stop fluid buildup without surgery
NCT ID NCT07662174
First seen Jun 27, 2026 ยท Last updated Jun 27, 2026
Summary
This early study tests whether a drug called sirolimus (rapamycin), given directly into the brain's fluid spaces, can prevent hydrocephalus after a severe brain hemorrhage. Hydrocephalus is a dangerous buildup of fluid that often requires a permanent surgical shunt. The trial will enroll 15 adults with bleeding from a ruptured aneurysm and will check safety, inflammation, and whether patients ultimately need a shunt.
What this could mean
Our plain-language read of the trial. This is informational only โ not medical advice or a prediction.
- Active substance
- Sirolimus (Rapamycin)
- What this could lead to
- If it works, this could lead to a non-surgical way to prevent hydrocephalus after brain bleeding, reducing the need for permanent shunts.
- What could go wrong
- This is a very early, small study with only 15 adults. The drug is delivered directly into the brain, which carries risks like infection or inflammation. Success is far from guaranteed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ANEURYSMAL SUBARACHNOID HEMORRHAGE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Massachusetts General Hospital Lunder 4 OR for adult surgeries
Boston, Massachusetts, 02114, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a blood pressure cuff shield the brain after a severe stroke?
- Can a gentle ear zap calm the Brain's overactive 'Fight or Flight' response?
- Spinal zap may stop deadly brain artery spasms after aneurysm
- Brain pressure sensor may guide better recovery after aneurysm rupture
- Nerve block may boost brain recovery after hemorrhagic stroke
- Massive study aims to solve brain bleed mystery