Antibiotic showdown: which strategy best protects gut health during implant infections?
NCT ID NCT07058415
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares three antibiotic combinations given to adults with suspected infections of joint or bone implants (like hip or knee replacements). The goal is to see how each antibiotic strategy changes the diversity of bacteria in the gut and whether it leads to more antibiotic-resistant germs. Researchers will collect stool samples before, during, and after treatment to track these changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
antibiotics (cefepime+daptomycin, piperacillin-tazobactam+daptomycin, or ceftobiprole)
What this could lead to
If one antibiotic strategy is found to better preserve gut bacteria and limit resistant germs, it could guide treatment choices for implant infections.
What could go wrong
This is a small, observational study that only looks at short-term changes in gut bacteria, not whether one antibiotic works better for curing the infection itself.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHU de NICE
Nice, France
Contact Email: •••••@•••••
Contact
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Ch Antibes
Antibes, France
Contact
Contact Email: •••••@•••••
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Ch Cannes
Cannes, France
Contact
Contact Email: •••••@•••••
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Ch Grasse
Grasse, France
Contact
Contact Email: •••••@•••••