Antibiotic showdown: which strategy best protects gut health during implant infections?
NCT ID NCT07058415
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares three antibiotic combinations given to adults with suspected infections of joint or bone implants (like hip or knee replacements). The goal is to see how each antibiotic strategy changes the diversity of bacteria in the gut and whether it leads to more antibiotic-resistant germs. Researchers will collect stool samples before, during, and after treatment to track these changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- antibiotics (cefepime+daptomycin, piperacillin-tazobactam+daptomycin, or ceftobiprole)
- What this could lead to
- If one antibiotic strategy is found to better preserve gut bacteria and limit resistant germs, it could guide treatment choices for implant infections.
- What could go wrong
- This is a small, observational study that only looks at short-term changes in gut bacteria, not whether one antibiotic works better for curing the infection itself.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU de NICE
Nice, France
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Ch Antibes
Antibes, France
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Ch Cannes
Cannes, France
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Ch Grasse
Grasse, France