Heart risk under the microscope: verapamil for cluster headaches

NCT ID NCT04406259

Ongoing Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how often a common heart side effect (first-degree atrioventricular block) occurs when verapamil is used at high doses to prevent cluster headaches. Researchers will monitor 60 patients starting or already on verapamil, using ECGs and blood tests. The goal is to better understand and track these heart conduction issues, not to test if verapamil works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Verapamil
What this could lead to: If successful, this could help doctors better understand and manage the heart-related side effects of high-dose verapamil when used for cluster headache prevention.
What could go wrong: This is a small, observational study focused on side effects, not on whether verapamil works for headaches. It may not lead to new treatments or change current practice.

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Conditions

The condition(s) this trial relates to.

cluster headache syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLUSTER HEADACHE

Contacts and locations

Locations

AP-HP Hôpital la Timone

Marseille, 13005, France
CHU de Nice

Nice, CHUN, 06003, France

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