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Could a common antibiotic beat stubborn joint infections?

NCT ID NCT05902221

Recruiting now Disease control Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether adding the antibiotic rifampicin to standard treatment improves outcomes for people with prosthetic joint infections caused by Cutibacterium acnes bacteria. These infections are hard to treat because the bacteria form a protective biofilm. The study involves 235 adults with infected hip, knee, or shoulder replacements who will receive either standard antibiotics alone or standard antibiotics plus rifampicin for 12 weeks. Researchers will track treatment failures and side effects to see if the combination works better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
rifampicin
What this could lead to
If adding rifampicin works, it could become a standard part of treatment for these stubborn joint infections, reducing the need for repeat surgeries.
What could go wrong
This is a phase 3 trial, but rifampicin may cause side effects like liver problems or drug interactions, and the infection might still return.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

periprosthetic joint infection prosthesis-related infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFECTIONS JOINT PROSTHETIC

Contacts and locations

Locations

  • AP-HM

    NOT_YET_RECRUITING

    Marseille, France

  • CH Annecy Genevois

    RECRUITING

    Annecy, France

  • CHRU Tours

    RECRUITING

    Tours, France

  • CHU Toulouse

    RECRUITING

    Toulouse, France

  • CHU de BORDEAUX

    RECRUITING

    Bordeaux, France

  • CHU de MONTPELLIER

    RECRUITING

    Montpellier, France

  • CHU de NICE

    RECRUITING

    Nice, 06200, France

  • CHU de Nantes

    RECRUITING

    Nantes, France

  • CHU de Rennes

    RECRUITING

    Rennes, France

  • Ch Tourcoing

    RECRUITING

    Tourcoing, France

  • Dianonesses croix saint simon

    RECRUITING

    Paris, France

  • HCL

    RECRUITING

    Lyon, France

  • Hôpital Ambroise Paré

    RECRUITING

    Boulogne, France

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