Could a common antibiotic beat stubborn joint infections?
NCT ID NCT05902221
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial investigates whether adding the antibiotic rifampicin to standard treatment improves outcomes for people with prosthetic joint infections caused by Cutibacterium acnes bacteria. These infections are hard to treat because the bacteria form a protective biofilm. The study involves 235 adults with infected hip, knee, or shoulder replacements who will receive either standard antibiotics alone or standard antibiotics plus rifampicin for 12 weeks. Researchers will track treatment failures and side effects to see if the combination works better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
rifampicin
What this could lead to
If adding rifampicin works, it could become a standard part of treatment for these stubborn joint infections, reducing the need for repeat surgeries.
What could go wrong
This is a phase 3 trial, but rifampicin may cause side effects like liver problems or drug interactions, and the infection might still return.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AP-HM
NOT_YET_RECRUITINGMarseille, France
Contact Email: •••••@•••••
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CH Annecy Genevois
RECRUITINGAnnecy, France
Contact Email: •••••@•••••
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CHRU Tours
RECRUITINGTours, France
Contact Email: •••••@•••••
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CHU Toulouse
RECRUITINGToulouse, France
Contact Email: •••••@•••••
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CHU de BORDEAUX
RECRUITINGBordeaux, France
Contact Email: •••••@•••••
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CHU de MONTPELLIER
RECRUITINGMontpellier, France
Contact Email: •••••@•••••
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CHU de NICE
RECRUITINGNice, 06200, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU de Nantes
RECRUITINGNantes, France
Contact Email: •••••@•••••
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CHU de Rennes
RECRUITINGRennes, France
Contact Email: •••••@•••••
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Ch Tourcoing
RECRUITINGTourcoing, France
Contact Email: •••••@•••••
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Dianonesses croix saint simon
RECRUITINGParis, France
Contact Email: •••••@•••••
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HCL
RECRUITINGLyon, France
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Hôpital Ambroise Paré
RECRUITINGBoulogne, France
Contact Phone: •••-•••-•••• Email: •••••@•••••