New drug cocktail aims to beat back aggressive leukemia in older adults
NCT ID NCT05260528
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether a newer chemotherapy drug called CPX-351 works better than standard chemo for adults aged 50 and older with a hard-to-treat form of acute myeloid leukemia (AML). About 248 people will be randomly assigned to receive either CPX-351 or standard chemo. The main goal is to see if CPX-351 leads to deeper remissions with less cancer left behind in the bone marrow.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CPX-351 (a combination of two chemotherapy drugs, daunorubicin and cytarabine, in a liposomal formulation)
What this could lead to
If CPX-351 works better than standard chemo, it could become a new first-line treatment for older adults with harder-to-treat AML, improving remission rates and reducing relapse.
What could go wrong
This is a phase 2 trial, so results are still early. CPX-351 may not prove superior to standard chemo, and both treatments have serious side effects like infection and organ damage.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CH Avignon
RECRUITINGAvignon, France
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CH de Roubaix
RECRUITINGRoubaix, France
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CHR Metz-Thionville Site Mercy
RECRUITINGMetz, France
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CHR Orléans
RECRUITINGOrléans, France
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CHRU Jean Minjoz
RECRUITINGBesançon, France
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CHU Amiens Picardie site Sud
RECRUITINGAmiens, France
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CHU Estaing
RECRUITINGClermont-Ferrand, France
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CHU Henri Mondor
RECRUITINGCréteil, France
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CHU d'Angers
NOT_YET_RECRUITINGAngers, France
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CHU de Bordeaux
RECRUITINGPessac, France
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CHU de Limoges
RECRUITINGLimoges, France
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CHU de Nantes
NOT_YET_RECRUITINGNantes, France
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CHU de Nice
RECRUITINGNice, France
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CHU de Saint Etienne
RECRUITINGSaint-Priest-en-Jarez, France
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CHU de Toulouse
RECRUITINGToulouse, France
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Centre Antoine Lacassagne
NOT_YET_RECRUITINGNice, France
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Centre Henri Becquerel
RECRUITINGRouen, France
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Centre Hospitalier Sud Francilien (CHSF)
RECRUITINGCorbeil-Essonnes, France
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Centre Hospitalier de Béziers
RECRUITINGBéziers, France
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Centre Hospitalier de Versailles, Site André Mignot
RECRUITINGLe Chesnay, France
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Groupe hospitalier de la région de Mulhouse et Sud-Alsace, Hôpital Emile Muller
RECRUITINGMulhouse, France
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Hopital Bretonneau
RECRUITINGTours, France
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Hopital Lyon Sud
RECRUITINGPierre-Bénite, France
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Hopital Necker
RECRUITINGParis, France
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Hoptial de la Conception APHM
RECRUITINGMarseille, France
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Hôpital Avicenne APHP
RECRUITINGBobigny, France
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Hôpital Claude HURIEZ, CHU Lille
RECRUITINGLille, France
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Hôpital Saint-Antoine
RECRUITINGParis, France
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Hôpital Saint-Louis
RECRUITINGParis, France
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Hôpital d'Instruction des Armée (HIA)
RECRUITINGClamart, France
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Hôpital de la Pitié Salpêtrière
RECRUITINGParis, France
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Institut Gustave Roussy
RECRUITINGVillejuif, France
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Institut Paoli Calmettes
RECRUITINGMarseille, France
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Institut d'hématologie de Basse Normandie (IHBN)
RECRUITINGCaen, France
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Institut de cancérologie du Gard
RECRUITINGNîmes, France
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