Blood test may spot lung cancer relapse months early

NCT ID NCT06443684

Ongoing Knowledge-focused Sponsor: Shanghai Chest Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 305 people with stage III non-small cell lung cancer who have specific genetic mutations. Researchers regularly test their blood for tiny traces of cancer DNA (minimal residual disease, or MRD) to see if it can predict when the cancer will come back. The goal is to find out if MRD testing is more accurate than standard scans for early detection of recurrence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a blood test that warns of lung cancer returning months before scans detect it.
What could go wrong: This is an observational study, not a treatment trial. It may show MRD is not a reliable predictor, or results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Affiliated Cancer Hospital of Harbin Medical University

Harbin, Heilongjiang, China
First Affiliated Hospital of Xiamen University

Xiamen, Fujian, China
Hunan Cancer Hospital

Changsha, Hunan, China
Qilu Hospital of Shandong University

Jinan, Shandong, 250000, China
Shandong Provincial Hospital

Jinan, Shandong, China
Shanghai Chest hospital

Shanghai, Shanghai Municipality, China
Shanxi Cancer Hospital

Taiyuan, Shanxi, China
The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China
The First Affiliated Hospital of USTC / Anhui Provincial Hospital

Hefei, Anhui, 230000, China
The First Affiliated Hospital of Xi 'an Jiaotong University

Xi’an, Shanxi, China
The First Affiliated Hospital of Zhejiang University

Hangzhou, Zhejiang, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450000, China
Zhejiang Cancer Hospital

Hangzhou, Zhejiang, China
Zhongshan Hospital Affiliated to Fudan University

Shanghai, Shanghai Municipality, China

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