Shanghai Chest Hospital

This study tests whether giving two drugs (SHR-A1811 and adebelimumab) before surgery can shrink or eliminate tumors in people with early-stage lung cancer that has a specific genetic change (HER2 alteration). About 40 adults with resectable non-small cell lung cancer will receiv…

This study tests a new drug, vebreltinib, combined with standard chemotherapy as a first treatment for people with advanced non-small cell lung cancer that has a specific marker (MET overexpression) and no other treatable gene changes. The goal is to see if the combination shrink…

This study looks at whether adding an SGLT2 inhibitor (a diabetes drug) to standard cancer treatment can help people with both advanced lung cancer and type 2 diabetes live longer or slow their cancer's growth. About 200 adults will take either the SGLT2 inhibitor pill or other d…

This study tests whether adding a nerve-blocking procedure (renal denervation) to standard heart ablation (pulsed-field ablation) can prevent atrial fibrillation from coming back early after treatment. About 86 adults with persistent AFib will be randomly assigned to get ablation…

This study tests whether a drug called sacubitril/valsartan, already used for heart failure and high blood pressure, can improve survival and reduce heart complications in 200 adults with advanced lung cancer who also have high blood pressure. Participants will take the medicatio…

This study looks at whether a robot-assisted bronchoscope can both take a tissue sample (biopsy) and destroy a lung nodule with heat (radiofrequency ablation) in a single procedure. It involves 76 adults with suspicious lung nodules who cannot or choose not to have surgery. The g…

This phase II trial tests whether adding the immunotherapy drug adebrelimab to standard chemotherapy and radiation before surgery can shrink tumors in people with locally advanced thymic carcinoma. About 31 participants will receive 2-4 cycles of this combination, then have surge…

This study tests whether dapagliflozin, a drug typically used for diabetes, can help prevent atrial fibrillation from coming back after a heart ablation procedure. The trial focuses on people with persistent AFib who have increased epicardial adipose tissue (fat around the heart)…

This study will test a new mobile 4D CT scanner during lung biopsies to see if it provides clearer, more detailed images of lung lesions. About 50 adults with small to medium-sized lung spots will take part. The goal is to improve diagnosis accuracy without changing the standard …