Herbal mix and cancer drug join forces to fight fluid in lungs

NCT ID NCT07670338

Not yet recruiting Disease control Sponsor: Shanghai Chest Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study tests whether adding a Chinese herbal formula (Xuanyin Ning) to a standard cancer drug (bevacizumab) can better control malignant pleural effusion—fluid buildup in the chest caused by advanced lung cancer. About 308 participants will receive either the herbal formula or a placebo, along with bevacizumab injected into the chest after drainage. The goal is to see if the combination improves fluid control, breathing, and quality of life over 8 weeks of treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Xuanyin Ning Formula (Chinese herbal granules) and bevacizumab (a cancer drug injected into the chest)
What this could lead to: If it works, this combination could offer a new way to better control fluid buildup in the chest, improving breathing and quality of life for people with advanced lung cancer.
What could go wrong: This is an early-stage trial with no phase listed, so results are uncertain. The herbal formula may not add benefit over standard care, and bevacizumab carries risks like bleeding or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

myeloproliferative disorder, chronic, with eosinophilia non-small cell lung carcinoma Pleural Effusion, Malignant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALIGNANT PLEURAL EFFUSIONS (MPE)

Contacts and locations

Locations

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Shanghai, Shanghai Municipality, 200032, China
Shanghai Chest Hospital

Shanghai, Shanghai Municipality, 200030, China
Shanghai Tenth People's Hospital Chongming Branch

Shanghai, Shanghai Municipality, 202157, China
The First Affiliated Hospital of Xinxiang Medical University

Xinxiang, Henan, 453100, China
Weifang Traditional Chinese Medicine Hospital 或 Weifang Traditional Chinese Hospital

Weifang, Shandong, 261041, China
Wuhan First Hospital

Wuhan, Hebei, 430022, China
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine

Shanghai, Shanghai Municipality, 200437, China

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