Brain-Lining cancer in breast cancer patients: could a reservoir pump chemo directly to the target?
NCT ID NCT06230055
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is for people with HER2-negative breast cancer that has spread to the lining of the brain (leptomeningeal metastasis). It compares standard chemotherapy given through the veins or by mouth to the same treatment plus extra chemotherapy delivered directly into the spinal fluid through a small device called an Ommaya reservoir, which is placed under the scalp. The goal is to see if the combination helps control the brain lining cancer longer and improves quality of life. About 37 participants will be randomly assigned to one of the two groups.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Chemotherapy drugs (e.g., methotrexate) given through an Ommaya reservoir into the spinal fluid, plus standard systemic chemotherapy
- What this could lead to
- If it works, this approach could offer better control of cancer spread to the brain lining and improve quality of life for patients with this difficult-to-treat condition.
- What could go wrong
- This is a small, early-phase trial with only 37 participants, so results may not apply to everyone. The added procedure carries risks like infection or bleeding, and the benefit over standard care is not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University
RECRUITINGShanghai, Shanghai Municipality, 200032, China
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Other studies related to the condition(s) this trial covers.
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