Spinal fluid chemo combo shows promise for advanced lung cancer
NCT ID NCT05805631
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests a combination of pemetrexed (given into the spinal fluid) and a tyrosine kinase inhibitor for people with a specific type of lung cancer (EGFR-mutant NSCLC) that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis) after the drug osimertinib stops working. The study aims to see if this approach can control the disease and improve survival. About 23 adults will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pemetrexed (given into the spinal fluid) plus a tyrosine kinase inhibitor
What this could lead to
If it works, this could offer a new treatment option for people with lung cancer that has spread to the lining of the brain and spinal cord after standard therapy fails.
What could go wrong
This is a small, early-phase study with only 23 participants, so results may not apply to everyone. The treatment involves injecting chemotherapy into the spinal fluid, which carries risks like infection or nerve damage.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Department of Chest Medicine, Taipei Veterans General Hospital
RECRUITINGTaipei, Taiwan, 11217, Taiwan
Contact Email: •••••@•••••
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