Spinal fluid chemo combo shows promise for advanced lung cancer
NCT ID NCT05805631
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests a combination of pemetrexed (given into the spinal fluid) and a tyrosine kinase inhibitor for people with a specific type of lung cancer (EGFR-mutant NSCLC) that has spread to the lining of the brain and spinal cord (leptomeningeal metastasis) after the drug osimertinib stops working. The study aims to see if this approach can control the disease and improve survival. About 23 adults will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pemetrexed (given into the spinal fluid) plus a tyrosine kinase inhibitor
- What this could lead to
- If it works, this could offer a new treatment option for people with lung cancer that has spread to the lining of the brain and spinal cord after standard therapy fails.
- What could go wrong
- This is a small, early-phase study with only 23 participants, so results may not apply to everyone. The treatment involves injecting chemotherapy into the spinal fluid, which carries risks like infection or nerve damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Department of Chest Medicine, Taipei Veterans General Hospital
RECRUITINGTaipei, Taiwan, 11217, Taiwan
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Other studies related to the condition(s) this trial covers.
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