New drug cocktail shows promise in rare stomach cancer trial
NCT ID NCT06109467
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether adding the drug neratinib to a standard combination of chemotherapy, trastuzumab, and pembrolizumab can shrink tumors in people with HER2-positive gastroesophageal cancers. The study includes 8 participants and aims to measure how many respond to treatment. The approach targets cancers that overexpress HER2, a protein that helps cancer grow.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Neratinib (a targeted cancer drug) combined with trastuzumab, pembrolizumab, and FOLFOX chemotherapy
- What this could lead to
- If successful, this could point toward a more effective treatment option for people with HER2-positive gastroesophageal cancers.
- What could go wrong
- This is a very small, early-phase trial with only 8 participants, so results may not apply to everyone. The drug combination may cause significant side effects or fail to improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Moffitt Cancer Center
Tampa, Florida, 33612, United States
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