New chemo timing strategies aim to outsmart aggressive childhood cancer

NCT ID NCT04388839

Ongoing Disease control Sponsor: H. Lee Moffitt Cancer Center and Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests four different chemotherapy schedules in children and adults with a rare, aggressive muscle cancer that has spread. Participants choose from a first-strike approach, a first-strike followed by maintenance, an adaptive schedule, or standard chemo. The goal is to see which timing works best to delay cancer return and improve survival.

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Conditions

The condition(s) this trial relates to.

alveolar rhabdomyosarcoma rhabdomyosarcoma sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHABDOMYOSARCOMA

Contacts and locations

Locations

Carolinas Medical Center, Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Children's Hospital of Colorado

Aurora, Colorado, 80045, United States
Cleveland Clinic

Cleveland, Ohio, 44106, United States
Connecticut Children's Medical Center

Hartford, Connecticut, 06106, United States
Duke Children's Hospital

Durham, North Carolina, 27710, United States
Johns Hopkins All Children's Hospital

St. Petersburg, Florida, 33701, United States
MD Anderson

Houston, Texas, 77030, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Montefiore Medical Cancer Center

The Bronx, New York, 10467, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Primary Children's Medical Center/Utah

Salt Lake City, Utah, 84113, United States
Roswell Park Comprehensive Cancer Center

Buffalo, New York, 14263, United States
University of Alabama at Birmingham Comprehensive Cancer Center

Birmingham, Alabama, 35294, United States
University of Florida

Gainesville, Florida, 32610, United States
University of Miami - Sylvester Comprehensive Cancer Center

Miami, Florida, 33136, United States
University of North Carolina Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Vanderbilt - Ingram Cancer Center

Nashville, Tennessee, 37232, United States

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