New chemo timing could change treatment for rare childhood cancer

NCT ID NCT04388839

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 22 times

Summary

This study tests four different chemotherapy schedules in children with a rare, aggressive muscle cancer that has spread. The goal is to see if changing when and how chemo is given can keep the cancer away longer and cause fewer side effects. Patients and their doctors choose from one of four approaches, including a first strike, maintenance, adaptive timing, or standard chemo.

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Contacts and locations

Locations

  • Carolinas Medical Center, Levine Cancer Institute

    Charlotte, North Carolina, 28204, United States

  • Children's Hospital of Colorado

    Aurora, Colorado, 80045, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44106, United States

  • Connecticut Children's Medical Center

    Hartford, Connecticut, 06106, United States

  • Duke Children's Hospital

    Durham, North Carolina, 27710, United States

  • Johns Hopkins All Children's Hospital

    St. Petersburg, Florida, 33701, United States

  • MD Anderson

    Houston, Texas, 77030, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Montefiore Medical Cancer Center

    The Bronx, New York, 10467, United States

  • Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

  • Primary Children's Medical Center/Utah

    Salt Lake City, Utah, 84113, United States

  • Roswell Park Comprehensive Cancer Center

    Buffalo, New York, 14263, United States

  • University of Alabama at Birmingham Comprehensive Cancer Center

    Birmingham, Alabama, 35294, United States

  • University of Florida

    Gainesville, Florida, 32610, United States

  • University of Miami - Sylvester Comprehensive Cancer Center

    Miami, Florida, 33136, United States

  • University of North Carolina Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • Vanderbilt - Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.