H. Lee Moffitt Cancer Center And Research Institute

This early-phase trial tests a personalized vaccine made from a patient's own tumor DNA. The goal is to train the immune system to recognize and attack any remaining breast cancer cells after standard chemotherapy and surgery. The study enrolls 16 people with high-risk triple neg…

This study tests whether combining two drugs, cemiplimab and ziv-aflibercept, can shrink or stop the growth of metastatic uveal melanoma—a rare eye cancer that has spread to other parts of the body. About 32 adults with this condition will receive the treatment to see if it is sa…

This study is for people with a specific type of breast cancer (HR+/HER2-) that has spread to the brain. It tests whether adding a targeted drug called abemaciclib to precise radiation therapy can better control the brain tumors. About 31 participants will receive both treatments…

This study tests whether special MRI scans can help doctors deliver higher doses of radiation to the most aggressive parts of a high-grade soft tissue sarcoma. About 43 adults with this rare cancer will receive radiation guided by these scans before surgery. The goal is to see if…

This early-phase trial tests a new treatment for men with advanced prostate cancer that has spread to the bone and no longer responds to standard therapies. The treatment involves taking a patient's own immune cells (gamma delta T cells), modifying them in a lab to better recogni…

This early-stage study tests if giving the drug cemiplimab before tumor removal surgery is safe for people with Merkel cell carcinoma or cutaneous squamous cell carcinoma. About 36 adults with stage I-II or locally advanced disease will receive the drug and then have surgery. Res…

This study tests a treatment called KTE-X19, a type of CAR T-cell therapy, in adults with B-cell acute lymphoblastic leukemia (B-ALL) who are in remission but still have tiny amounts of cancer cells (minimal residual disease, or MRD). The goal is to see if this therapy can preven…

This study tests whether adding the drug pirtobrutinib to standard CAR T-cell therapy (brexu-cel) can help people with mantle cell lymphoma that has come back or stopped responding to treatment. About 60 adults will be randomly assigned to receive pirtobrutinib either before or a…

This study tests whether digoxin, a heart medication, can help children and young adults with a specific type of relapsed brain cancer called non-WNT/non-SHH medulloblastoma. About 23 participants aged 1 to 29 will receive digoxin to see if it stops the cancer from growing for at…

This study tests whether giving immunotherapy before and after surgery helps people with advanced melanoma. About 90 adults with stage III or IV melanoma will receive treatment based on their tumor's biomarkers. The goal is to see if this approach leads to better tumor shrinkage …

This study tests a two-step treatment for a rare eye cancer (uveal melanoma) that has spread only to the liver. First, a chemotherapy drug is delivered directly to the liver through a special procedure. Then, an immunotherapy drug is given to help the immune system attack the can…

This early-phase study tests whether adding aspirin to standard chemotherapy can reduce immune-suppressing cells inside ovarian tumors. About 100 women with ovarian, fallopian tube, or peritoneal cancer will take aspirin alongside chemo before surgery. Researchers will compare tu…

This study tests whether taking itacitinib pills before CAR-T cell therapy can help people with diffuse large B-cell lymphoma live longer without their cancer growing. About 27 adults who are eligible for CAR-T treatment will receive itacitinib once daily before their standard CA…

This study tests whether the immunotherapy drug pembrolizumab can shrink or slow the growth of advanced cutaneous sarcomas (a rare type of skin cancer). About 17 adults with this cancer will receive pembrolizumab every three weeks. The main goal is to see how many patients respon…

This study tests a new way to give chemotherapy for people with metastatic Ewing sarcoma, a rare and aggressive cancer. The approach uses principles from evolution to first hit the cancer hard, then target resistant cells, and finally use long-term maintenance to try to wipe out …

This study looks at whether people with acute myeloid leukemia (AML) whose cancer is well-controlled by a combination of two drugs (azacitidine or decitabine plus venetoclax) can safely stop treatment for a while after one year. The goal is to see if they can stay in remission wi…

This study tests whether combining two drugs, dostarlimab and niraparib, can shrink tumors or slow the growth of advanced penile cancer in patients whose cancer has worsened after chemotherapy. About 25 adults with stage III or IV penile cancer will receive the combination treatm…

This study tests a new treatment for advanced melanoma that uses a patient's own immune cells, called TIL, which are boosted with a protein called CD40L to help them fight cancer better. About 36 people with different types of advanced melanoma that did not respond to standard tr…

This study tests whether adding a personalized dendritic cell vaccine to standard chemotherapy and targeted therapy can help people with HER2-positive breast cancer. About 53 participants will receive the vaccine alongside standard drugs before surgery. The main goal is to see if…

This study tests whether adding a targeted drug (sacituzumab govitecan) and an immunotherapy (zimberelimab) to precise brain radiation can help people with metastatic triple negative breast cancer that has spread to the brain. About 31 adults will receive the combination and be m…

This study tests two drugs, olaparib and pembrolizumab, together in people with advanced uveal melanoma, a rare eye cancer that has spread. The goal is to see if the combination can shrink tumors or slow the disease. About 37 adults will take part, and the main focus is on how ma…

This study tests whether adding an immune-boosting vaccine (Sipuleucel-T) to ongoing hormone therapy can better activate the immune system in men with metastatic prostate cancer that has started to progress. About 26 men whose cancer is growing despite standard hormone treatments…

This early-phase trial tests a special immune cell therapy (CD40L TIL) combined with the drug nivolumab for people with advanced non-small cell lung cancer that has specific gene changes (EGFR, ALK, ROS1, or HER2). About 20 participants whose cancer worsened after standard treatm…

This study tests a new way of giving already-approved drugs to people with hormone-positive metastatic breast cancer. The idea is to use a 'first strike, second strike' approach, inspired by how extinctions happen in nature, to make the treatment more effective. The study will en…

This early-phase study tests the safety of combining two chemotherapy drugs, CPX-351 and gemtuzumab ozogamicin, in 18 adults aged 18–70 with newly diagnosed acute myeloid leukemia (AML). The goal is to find the highest safe dose and see how many patients achieve complete remissio…

This study looks at whether giving additional treatment after surgery can reduce the chance of melanoma returning in people with advanced stage III or IV melanoma that has a BRAF V600 mutation. About 50 participants will receive a combination of drugs (encorafenib and binimetinib…

This study tests a combination of three immunotherapy drugs (IL2, ipilimumab, and nivolumab) in people with advanced melanoma that can't be removed by surgery and has stopped responding to prior anti-PD1 treatment. The goal is to see if this new approach can shrink tumors or slow…

This study looks at how well the drug pembrolizumab (with or without chemotherapy) works in Black patients with advanced non-small cell lung cancer. About 318 people will join, and researchers will track survival and tumor response. The goal is to find out which patients benefit …

This study tests a mindfulness-based program to help cancer survivors stop smoking and reduce heavy drinking. Researchers will compare the program to standard care in 600 survivors across Florida. The goal is to see if mindfulness can improve health behaviors and quality of life.

This study tests whether combining axitinib (a targeted therapy) with ipilimumab (an immunotherapy) can shrink tumors or slow disease in people with advanced melanoma that has stopped responding to standard treatment. About 25 adults with unresectable melanoma will receive both d…

This early-phase trial tests an investigational drug called ropeginterferon in 38 adults with cutaneous T-cell lymphoma (CTCL), a rare type of skin cancer. Participants must have tried at least two prior treatments without success. The main goals are to find the safest dose and s…

This early study tests whether combining a special immune-boosting vaccine (DC1) with the drug elacestrant is safe and doable for people with a common type of advanced breast cancer (HR+ HER2-). About 18 participants will receive the treatment for 8 weeks. The goal is to see if t…

This study tests if automated, personalized text messages can help people living with HIV quit smoking. Researchers will enroll 800 smokers in Cambodia and use text-based coaching plus carbon monoxide breath tests to check progress. The goal is to find a simple, scalable way to r…

This study tests whether adding venetoclax to standard chemotherapy (CLAG-M) helps adults with relapsed or refractory acute myeloid leukemia (AML) achieve deeper remission and live longer without the cancer returning. About 52 participants will be randomly assigned to receive eit…

This early-stage trial tests a combination of two drugs, avapritinib and decitabine, for people with systemic mastocytosis with an associated hematologic neoplasm (SM-AHN), a rare and hard-to-treat blood disease. The goal is to find a safe dose that controls both the mastocytosis…

This early-phase study tests the safety of giving specially grown immune cells (T cells) to people with advanced HER2-positive breast cancer. Participants first receive a vaccine and two drugs (pepinemab and trastuzumab) to boost their immune system. The goal is to find the highe…

This early-phase trial tests an experimental vaccine made from a patient's own immune cells, designed to target two cancer-related proteins (HER2 and HER3). The vaccine is injected directly into the tumor along with standard chemotherapy before surgery. The study includes about 3…

This study compares four different ways of taking the drug vismodegib for advanced basal cell carcinoma. The goal is to see if personalized, intermittent dosing (taking breaks) works as well as continuous daily dosing but with fewer side effects. About 34 adults with advanced ski…

This study tests a drug called enfortumab vedotin in people with advanced colorectal or liver cancer that has spread or cannot be removed. Participants must have already tried at least one standard treatment. The goal is to see if the drug can shrink tumors or slow the disease. A…

This study tests whether the drug afatinib can shrink tumors in people with advanced squamous cell skin cancer that cannot be treated with surgery or radiation. About 25 adults will take afatinib pills, and researchers will measure how many patients respond and how long the cance…

This study tests whether using a patient's genetic profile to customize radiation doses can better control triple negative breast cancer after lumpectomy. About 86 participants will receive genomically guided radiation therapy. The goal is to prevent cancer from returning in the …

This early-phase study tests the safety and best dose of asciminib, a daily pill, in adults with a certain type of leukemia (Ph+ ALL) who have already received a stem cell transplant or CAR T therapy. The goal is to see if taking asciminib afterward can help prevent the cancer fr…

This study tests a new two-step approach for men with advanced prostate cancer that has stopped responding to standard hormone therapy. First, patients receive a high dose of testosterone, followed by a targeted radioactive drug. The goal is to see if this combination is safe and…

This study tests whether a combination of two drugs, ACR-368 and low-dose gemcitabine, can shrink tumors or slow cancer growth in people with head and neck cancer that has come back or spread. About 43 adults will receive the drugs every two weeks. The goal is to see if the treat…

This study tests whether adding the drug elranatamab after CAR-T cell therapy can help people with high-risk relapsed myeloma live longer without their cancer getting worse. About 39 participants who have already received CAR-T will receive elranatamab as maintenance. The goal is…

This early-stage study tests a new treatment for recurrent ovarian cancer using a patient's own immune cells, modified to recognize and attack cancer cells. Ten adults with ovarian, fallopian tube, or peritoneal cancer will receive an infusion of these engineered T cells, with or…

This study tests whether a combination of two drugs, tafasitamab and lenalidomide, can shrink or control large B-cell lymphoma that remains after a prior CAR-T cell therapy. About 28 adults with this type of lymphoma will receive the treatment for up to 12 months. The goal is to …

This early-phase study is testing whether adding a drug called calaspargase pegol to standard chemotherapy (Hyper-CVAD) is safe and tolerable for young adults newly diagnosed with acute lymphoblastic leukemia (ALL). About 7 participants will receive the combination after completi…

This study tests a combination of two drugs, rituximab and zanubrutinib, in people with untreated follicular lymphoma or marginal zone lymphoma. The goal is to see how well the combo works and if it is safe. About 43 participants will receive the treatment, and researchers will m…

This early-stage study is for adults with a specific genetic form of acute myeloid leukemia (FLT3-mutated) that has come back or not responded to prior treatment. It combines two drugs—vyxeos and gilteritinib—to see if they work better together. The main goal is to find the safes…

This study tests whether giving focused radiation to large tumors before CAR-T cell therapy can help control aggressive large B-cell lymphoma that has come back or not responded to treatment. About 27 adults with tumors at least 5 cm will receive this combination. The goal is to …

This study compares two drugs, ruxolitinib and prednisone, as the first treatment for chronic graft-versus-host disease (cGVHD), a complication after bone marrow transplant. About 120 adults who need systemic therapy for cGVHD will be randomly assigned to receive one of the two d…

This study is testing a new mouth swab test that looks for HPV DNA and certain gene changes to catch throat cancer early. Researchers will compare test results from 200 people with throat cancer and 200 healthy volunteers. If successful, this test could lead to a simple, non-inva…

This study looks at whether giving people personalized information about their skin cancer risk can encourage them to protect their skin. About 2,900 adults from community health centers will provide a saliva sample for genetic testing and answer questions about their sun habits.…

This study tests a remote nutrition program (STRONG) for 80 adults with advanced gastroesophageal cancer who are starting chemotherapy or radiation. The program uses a food-logging app and dietitian visits to see if it reduces malnutrition better than usual care. The main goal is…

This study tests whether the MIND diet, a diet designed to support brain health, can improve memory, thinking, and fatigue in breast cancer survivors. Researchers will enroll 200 survivors who have completed treatment and still have cognitive problems. Participants will follow th…

This study tests a program that gives extra nutrition help to people with pancreatic cancer after they have surgery. The program uses a mobile app and remote dietitian support to help patients eat well during recovery. The goal is to see if the program is easy to use and helps pa…

This study tests whether using MRI scans to adjust radiation doses during treatment can reduce damage to nearby healthy organs in people with head and neck cancer. About 35 participants will receive standard radiation therapy, but part of the dose will be personalized based on MR…

This study tests whether a remote exercise and nutrition program can help people with pancreatic cancer get stronger before surgery. Researchers want to see if the program is practical and acceptable for patients. The study will enroll 26 adults who are scheduled for surgery afte…

This study tests whether a smartphone app that uses augmented reality (AR) can help people quit smoking when used alongside standard quitline counseling. The app shows smoking-related cues to help users manage cravings. The trial will enroll 3,600 adult daily smokers and measure …

This study looks at whether regular brain MRIs can detect cancer that has spread to the brain in people with stage IV breast cancer who have no brain symptoms. About 170 participants with different breast cancer types will get brain scans at the start and again after 6 months or …

This study looks at whether getting a brain MRI every 6 months can find brain tumors earlier in people with stage IV breast cancer who have no brain symptoms. About 156 participants will be randomly assigned to either regular scans or standard care (scans only if symptoms appear)…

This study looks at how often breast cancer that has spread to lymph nodes also spreads to other parts of the body after chemotherapy and surgery. About 120 people will get CT scans at the start and again 6 months later to check for distant spread. The goal is to learn more about…

This study is creating a smartphone-based system to help cancer patients stop smoking. Researchers will test if the tool is easy to use and if patients like it. About 90 adult cancer patients who smoke will take part. The goal is to make this resource available to researchers acr…

This study follows 100 adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) to see how their quality of life, fatigue, and symptoms change over 2 years after starting treatment. Researchers compare two common treatment types to help future patients k…

This study is testing whether a group of experts, called the Evolutionary Tumor Board, can come up with new treatment plans for 35 people whose cancer cannot be cured. The goal is to see if they can create a different plan for at least 80% of participants. This research does not …

This study provides cancer education and outreach to 1,200 adults in Florida and Puerto Rico. The goal is to increase cancer awareness, community engagement, and participation in cancer research. Participants attend educational events, training programs, and provide feedback to r…

This study looks at whether an exercise program before surgery (called prehabilitation) is practical and acceptable for people with esophageal cancer. About 20 patients will take part to see if they stick with the program and if it helps with recovery. The goal is to gather infor…

This study is for people with pancreatic cysts or other pancreas issues. Researchers will collect blood, tissue, and scan data from over 1,100 participants to create a large database. The goal is to develop noninvasive tools that predict which cysts may become cancerous, helping …

This study looks at how obesity may cause pancreatic cancer to grow differently in African American and White people. Researchers will compare genes, fat tissue, and tumor features in 125 adults to find better treatments. The goal is to understand these differences, not to test a…

This study is for people with pancreatic cancer. It uses artificial intelligence to find early signs of cachexia, a condition that causes severe weight loss and muscle wasting. Researchers will also see if diet and exercise programs are practical and helpful for patients. The goa…

This study looks at 60 men with prostate cancer who had a high-risk genetic test (Decipher score >0.45). They will get a special PSMA-PET scan two years after their initial treatment to see if the cancer has spread. The goal is to learn how well the genetic test predicts early me…

This study tests outreach and digital strategies to help more Black and Hispanic patients join cancer treatment trials at Moffitt Cancer Center. Researchers will compare enrollment rates in areas that receive the extra support versus those that do not. The goal is to make cancer …

This study is testing whether a group of specialists from different hospitals can come up with new treatment ideas for children and young adults with cancer that is very hard to cure. The team will review each patient's case and suggest a different approach than what their own do…

This study looks at whether certain blood and tissue markers can help doctors tell if a lung nodule is cancer or not, predict if cancer will come back after surgery, and detect late recurrences. About 250 adults with suspicious lung nodules will provide samples and be followed ov…