New combo aims to boost CAR t power against tough lymphoma
NCT ID NCT06553872
First seen Nov 17, 2025 · Last updated Jun 16, 2026 · Updated 25 times
Summary
This study tests whether adding the drug pirtobrutinib to standard CAR T-cell therapy (brexu-cel) can help people with mantle cell lymphoma that has come back or stopped responding to treatment. About 60 adults will be randomly assigned to receive pirtobrutinib either before or after CAR T infusion. The goal is to see if the combination improves how long the cancer stays away, while monitoring side effects like severe immune reactions.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Stanford Cancer Center
NOT_YET_RECRUITINGStanford, California, 94305, United States
Contact Phone: •••-•••-••••
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Univ of Miami - Sylvester Comprehensive Cancer Center
RECRUITINGMiami, Florida, 33136, United States
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Conditions
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