H. Lee Moffitt Cancer Center And Research Institute

This early-stage trial tests a personalized vaccine made from a patient's own immune cells and tumor DNA. It is for people with high-risk triple negative breast cancer who still have tumor left after standard chemotherapy and surgery. The goal is to see if the vaccine is safe and…

This study tests whether giving targeted radiation to large tumors (at least 5 cm) before CAR-T cell therapy can improve cancer control in people with aggressive large B-cell lymphoma that has returned or not responded to treatment. About 27 participants will receive the radiatio…

This study tests whether using special imaging (radiomics) to find the most active parts of a tumor can allow doctors to safely give higher radiation doses there. The goal is to kill more cancer cells before surgery, improving the chance of complete removal and long-term control.…

This study looks at whether adding aspirin to standard chemotherapy can help the immune system fight ovarian, fallopian tube, or peritoneal cancer better. About 100 women will take aspirin along with their chemo before surgery. Researchers will measure changes in immune cells wit…

This study tests whether two drugs, cemiplimab and ziv-aflibercept, can shrink or stop the growth of metastatic uveal melanoma, a rare eye cancer that has spread to other parts of the body. About 32 adults with this condition will receive the combination treatment. The main goal …

This study tests whether using MRI scans during radiation therapy can help doctors adjust the treatment to better target the tumor and avoid harming nearby healthy organs. About 35 adults with head and neck cancer will receive standard radiation plus an extra MRI-guided boost. Th…

This study tests whether adding venetoclax to standard chemotherapy (CLAG-M) helps people with relapsed or treatment-resistant acute myeloid leukemia (AML) achieve deeper remission. About 52 adults aged 18-80 will be randomly assigned to receive either the combo or chemo alone. T…

This early-stage study tests a combination of two drugs, Vyxeos and Gilteritinib, for adults with a specific genetic form of acute myeloid leukemia (FLT3-mutated) that has returned or not responded to prior treatment. The goal is to find the safest dose and see how well it contro…

This study tests whether using a tumor's genetic profile to customize radiation doses can better control triple negative breast cancer after lumpectomy. About 86 participants will receive radiation tailored to their individual risk, with the goal of preventing cancer from returni…

This study tests a two-step treatment for people with a rare eye cancer (uveal melanoma) that has spread only to the liver. First, a chemotherapy drug is delivered directly to the liver through a special procedure. Then, a targeted immunotherapy drug is given to help the immune s…

This study tests whether ruxolitinib works better than the standard steroid prednisone as the first treatment for chronic graft-versus-host disease (cGVHD), a complication after bone marrow transplant. About 120 adults who need systemic therapy for cGVHD will be randomly assigned…

This study tests whether adding a targeted cancer pill (abemaciclib) to precise radiation can better control breast cancer that has spread to the brain. About 31 adults with a specific type of breast cancer (HR+/HER2-) will receive both treatments. The goal is to see how long the…

This study compares four different dosing schedules of the drug vismodegib in 34 adults with advanced basal cell carcinoma. The goal is to see if personalized, intermittent dosing works as well as continuous daily dosing while reducing side effects. Participants will be followed …

This early-phase study tests the safety of combining two chemotherapy drugs, CPX-351 and gemtuzumab ozogamicin, in adults aged 18-70 with newly diagnosed acute myeloid leukemia. The goal is to find the highest safe dose and see how well the combination works at achieving remissio…

This study tests if automated, personalized text messages can help 800 smokers living with HIV in Cambodia quit smoking. Participants will receive tailored messages and set a quit date within two weeks. The study will check if they have stopped smoking after 3 and 6 months using …

This study tests whether adding the immunotherapy Sipuleucel-T (Provenge) to standard hormone therapy can better control metastatic prostate cancer that has started to progress. About 26 men with asymptomatic or mildly symptomatic disease will be randomly assigned to receive Sipu…

This study tests a combination of two drugs, ACR-368 and low-dose gemcitabine, in people with head and neck cancer that has come back or spread. The goal is to see if the treatment can shrink tumors and how safe it is. About 43 adults will receive the drugs every two weeks as lon…

This study tests whether adding the targeted drug pirtobrutinib to standard CAR T-cell therapy can better control mantle cell lymphoma that has come back or stopped responding to treatment. About 60 adults will be randomly assigned to receive the drug before or after the cell inf…

This early-stage trial tests a personalized treatment for men with advanced prostate cancer that has spread to bones and stopped responding to standard therapies. The patient's own immune cells are collected, genetically modified to recognize and attack prostate cancer cells, and…

This early-stage trial tests a special immune cell therapy (CD40L TIL) combined with the drug nivolumab for people with advanced non-small cell lung cancer that has specific gene changes (EGFR, ALK, ROS1, or HER2). About 20 adults whose cancer worsened after standard treatments w…

This study tests whether taking itacitinib pills before CAR-T cell therapy can help people with diffuse large B-cell lymphoma (DLBCL) live longer without their cancer growing. About 27 adults who are already eligible for CAR-T treatment will take itacitinib once daily before thei…

This study tests whether a remote exercise and nutrition program before surgery can help people with pancreatic cancer get stronger and recover better. About 26 adults with borderline resectable pancreatic cancer will take part. The program is done at home and focuses on improvin…

This study tests whether a diet called MIND can improve memory, focus, and thinking in breast cancer survivors who have ongoing 'brain fog' after treatment. Researchers will enroll 200 women who finished treatment 6 months to 3 years ago. Participants will follow the MIND diet fo…

This study tests a program that gives extra nutrition help to people with pancreatic cancer after they have surgery. Participants use a mobile app to log their meals and get support from a dietitian. The goal is to see if the program is easy to use and helps patients feel satisfi…

This study is for Black patients with advanced non-small cell lung cancer who have not had treatment yet. It tests how well the drug pembrolizumab, with or without chemotherapy, works in real-world settings. Researchers will also look for biomarkers in the blood that might predic…

This study follows 100 adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are starting treatment. Researchers will measure quality of life, fatigue, and symptoms at several points over two years to see how different treatments affect daily livi…

This study offers cancer education programs to adults in Florida and Puerto Rico. The goal is to increase cancer awareness and encourage participation in cancer research. Participants attend events, complete online training, or become lay health promoters. The study does not test…

This study is creating a mobile health (mHealth) system to help cancer patients stop smoking. Researchers will test if the system is easy to use and acceptable to patients. About 90 adults with cancer who smoke will try the app. The goal is to build a resource that can be used ac…

This study is testing whether a special team of doctors and scientists, called the Evolutionary Tumor Board, can come up with new treatment plans for 35 people whose cancer is considered incurable. The goal is to see if they can create a personalized strategy that is different fr…

This study tests whether outreach, navigation, and digital tools can help more Black and Hispanic patients join cancer treatment trials. Researchers will compare enrollment rates in areas that receive the intervention versus those that do not. The goal is to make cancer research …

This study looks at whether a special type of PET scan (PSMA-PET) can find early signs of prostate cancer that has spread in men who had a high-risk gene test (Decipher score >0.45). The study will include 60 men who were already part of a larger study. They will get a PSMA-PET s…