H. Lee Moffitt Cancer Center And Research Institute

This early-phase study tested the safety and best dose of a drug called Minnelide in 27 adults with acute myeloid leukemia (AML) that had returned or not responded to prior therapy. The goal was to find the highest safe dose and check for side effects. The study was terminated ea…

This early-phase study tested the drug siltuximab in 6 adults with large granular lymphocytic leukemia (LGLL), a rare blood cancer. The goal was to see if the drug is safe and can shrink or control the disease. The study was terminated early, so results are limited.

This study tested the drug umbralisib in 12 people with chronic lymphocytic leukemia (CLL) who had not yet received treatment. The goal was to see how well it controlled the disease and what side effects occurred. The study was stopped early, but results showed some patients had …

This study tested the drug fedratinib as a maintenance treatment after a stem cell transplant for people with myeloproliferative neoplasms (a type of blood cancer). The goal was to see if it could prevent the cancer from coming back. The trial was stopped early and included only …

This study aimed to see if giving two drugs—pembrolizumab (a PD-1 blocker) followed by ibrutinib—could improve the immune system's ability to fight high-risk chronic lymphocytic leukemia (CLL) in people who had not yet received treatment. Only 5 participants were enrolled before …