H. Lee Moffitt Cancer Center And Research Institute

This early-phase study tested a personalized vaccine made from a patient's own immune cells, designed to target a protein called HER-2 found on some aggressive breast cancers. The goal was to see if the vaccine was safe and could train the immune system to prevent the cancer from…

This study tested the drug nivolumab in 54 people with advanced biliary tract cancer (cancer of the bile ducts or gallbladder) that had not responded to prior chemotherapy. The goal was to see if nivolumab could shrink tumors or slow the cancer's growth. Nivolumab is an immunothe…

This early-stage study tested whether adding a drug called BMS-986004 to standard immune-suppressing medicine could help prevent acute graft-versus-host disease (GVHD) in 45 adults with blood cancers or disorders receiving a stem cell transplant. GVHD occurs when donor immune cel…

This early-phase study tested a combination of two drugs, trametinib and ceritinib, in 27 people with advanced melanoma that had stopped responding to standard treatments. The main goal was to find the safest dose and see if the combination could shrink tumors. While not a cure, …

This study tested a combination of two drugs, TAS 102 and ramucirumab, in 23 people with advanced stomach or gastroesophageal junction cancer that had not responded to prior treatments. The goal was to see if the combo was safe and could help patients live longer. Results focus o…

This study tested whether injecting a modified herpes virus (T-VEC) directly into tumors, alongside standard chemotherapy before surgery, could better eliminate triple negative breast cancer. The virus is designed to infect and destroy cancer cells while leaving healthy cells alo…

This study tested a treatment for advanced melanoma that uses a patient's own immune cells. 19 participants had their tumor-fighting cells (TILs) removed, grown in a lab, and then given back along with high-dose IL-2 after chemotherapy. The main goal was to see if this approach w…

This study tested a combination of two immunotherapy drugs—high-dose interleukin-2 (IL-2) and pembrolizumab (Keytruda)—in 27 adults with metastatic kidney cancer. The goal was to see if the combination could shrink or eliminate tumors. Participants received both drugs in a coordi…

This early-phase study tested a combination of two drugs, regorafenib and nivolumab, in 52 people with advanced colorectal cancer that had stopped responding to other treatments. The goal was to find the safest dose and see if the combination could help control the cancer. The st…

This early-phase study tested a vaccine made from patients' own immune cells to target HER2-positive breast cancer. 31 participants with stage II or III breast cancer received the vaccine alongside standard chemotherapy before surgery. The goal was to see if the vaccine could boo…

This study tested a stem cell transplant using a half-matched family donor for people with various blood cancers. The treatment used a milder chemotherapy and radiation regimen to prepare the body for the transplant. The goal was to see how many patients remained cancer-free 18 m…

This early-phase study tested a combination of two drugs—capecitabine (a chemotherapy pill) and cemiplimab (an immunotherapy)—in 13 people with hormone receptor-positive breast cancer that had spread. The main goal was to find the safest dose and see if the combo could shrink tum…

This study tested a program that combines weight loss tools with stress management techniques for Black women who have had breast cancer and are overweight. The goal was to see if the program was practical and helpful. 37 women took part in the 4-month program, and researchers me…

This study tested a two-step treatment for people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). First, patients received ofatumumab plus high-dose methylprednisolone, followed by ofatumumab and lenalidomide. The goal was to see if this com…

This early-phase study tested an experimental cell therapy called PRGN-3007 UltraCAR-T in 3 adults with advanced blood cancers (like leukemia and lymphoma) or triple-negative breast cancer. The main goal was to find a safe dose and see if the treatment could shrink tumors. Becaus…

This early-phase trial tested the safety of adding two drugs, pembrolizumab and vorinostat, to standard chemotherapy and radiation for people newly diagnosed with glioblastoma, an aggressive brain cancer. The study enrolled 21 participants to find the highest safe dose of vorinos…

This study tested a combination of two drugs, pembrolizumab and lenvatinib, in 20 adults with advanced neuroendocrine tumors that had worsened despite prior treatments. The goal was to see if the combination could shrink tumors or slow cancer growth, and to check for side effects…

This early-phase study tested whether a two-step treatment is safe for people with locally advanced pancreatic cancer that cannot be removed by surgery. First, doctors used electric pulses to destroy tumor cells, then gave an immunotherapy drug (pembrolizumab) to help the immune …

This study tested a powerful combination for people with advanced melanoma that has spread. It used a targeted drug (vemurafenib) together with a patient's own specially grown immune cells (T-cells) and high-dose IL-2 to boost the immune system. The goal was to see if this approa…

This early-phase trial tested a treatment that uses a patient's own immune cells (called TILs) to fight soft tissue sarcoma. Nine young adults received chemotherapy to prepare their bodies, then an infusion of their own TILs plus high-dose IL-2 to boost the immune response. The m…

This study tested a new drug called AZD1775 combined with standard chemotherapy (carboplatin and paclitaxel) in 42 people with advanced squamous cell lung cancer. The goal was to see if the combination could slow cancer growth or improve survival. Researchers measured how long pa…

This study tested whether using a negative pressure wound therapy device (a special vacuum bandage) for a longer time after surgery could lower the chance of wound infections in people with gastrointestinal cancer. About 290 patients took part. The goal was to see if this approac…

This early-phase study tested whether giving a type of precise radiation (stereotactic radiosurgery) after an immunotherapy drug (nivolumab) is safe and helps control tumors in people with breast cancer that has spread to the brain. Fourteen participants were enrolled to check fo…

This study tested whether combining two FDA-approved drugs, cetuximab and nivolumab, could help people with advanced head and neck cancer that has returned or spread. A total of 95 participants received the drug combination to find the safest dose and see if it improved survival.…

This study tested a combination of two chemotherapy drugs, nab-paclitaxel and gemcitabine, in 59 teenagers and young adults whose sarcoma (a type of bone or soft tissue cancer) had come back or was not responding to standard treatment. The goal was to see if the combo could shrin…

This study tested a smartphone app designed to help people who smoke and face financial or other challenges quit smoking. Over 500 participants used the app to track their smoking and get support. The goal was to see if the app helped them stop smoking for good.

This study tested a new drug combination (pacritinib, sirolimus, and tacrolimus) to prevent graft-versus-host disease (GVHD) in 40 people receiving stem cell transplants for blood cancers. GVHD occurs when donor cells attack the patient's body. The approach aims to reduce this ri…

This early-phase study tested a combination of the immunotherapy drug avelumab and whole brain radiotherapy in 16 adults with leptomeningeal disease, a rare condition where cancer spreads to the lining of the brain and spinal cord. The main goal was to find a safe dose and identi…

This pilot study tested a new combination treatment for people with advanced melanoma that has spread. It combined a patient's own immune cells grown in a lab (called TILs) with an immunotherapy drug called ipilimumab. The main goals were to see if the treatment was safe and poss…

This early-phase trial tested a combination of two drugs, IRX-2 and durvalumab, in 19 people with advanced head and neck cancer that could not be cured with standard treatments. The goal was to see if the combination was safe and could boost the immune system's attack on tumors. …

This study tested a new approach for people with advanced melanoma that can be surgically removed. Participants received a combination of two immunotherapies: one injected directly into the tumor (Tavo) and one given through a vein (nivolumab). After 12 weeks, they had surgery to…

This early-phase study tested a combination of two drugs—CG0070 (given directly into the bladder) and nivolumab (given through a vein)—in 21 people with muscle-invasive bladder cancer who were not eligible for the standard chemotherapy drug cisplatin. The main goal was to check s…

This early-phase study tested adding the drug pirfenidone to standard chemotherapy for people with advanced non-small cell lung cancer. The main goals were to find a safe dose and see if the combination could shrink tumors. 48 participants were enrolled, and the study is now comp…

This study tested a way to deliver three chemotherapy drugs directly to the tumor through an artery in adults with malignant pleural mesothelioma that cannot be removed by surgery. The goal was to see if this approach is safe and can control the disease. 34 people took part in th…

This study tested an experimental treatment for people with myelodysplastic syndrome (MDS) or secondary acute myeloid leukemia (AML) whose first therapy stopped working. Nineteen adults received a special infusion of immune cells from a mismatched unrelated donor, designed to att…

This early-phase study tested a new treatment called TBio-4101 for people with advanced melanoma that did not respond to standard therapies. The treatment uses a patient's own immune cells (TILs) that are selected and grown in the lab, then given back after chemotherapy to help f…

This early study tested whether giving a single dose of nivolumab with either ipilimumab or relatlimab before surgery is safe and possible for people with melanoma that has spread to the brain. Only one person took part, so results are very limited. The goal was to see how the dr…

This early-phase study tested a new drug combination (duvelisib plus BMS-986345) in 14 people with blood cancers like lymphoma, myeloma, and leukemia. The main goal was to find a safe dose and check for side effects. Researchers also looked at how well the cancer responded after …

This study tested a 12-week digital health coaching program for people with pancreatic cancer and their caregivers. The goal was to see if the program was easy to use and helpful. 20 participants from Moffitt Cancer Center took part in the pilot study.

This study tested a program that provides nutrition and supportive care remotely to adults with pancreatic cancer who are receiving chemotherapy. The goal was to see if the program was easy to use and if patients were satisfied with it. 50 participants were enrolled to track how …

This study tested a program called STRONG-PD that provides nutrition support remotely to people with gastrointestinal cancer that has spread to the lining of the belly. Ten patients who had surgery and chemotherapy participated. The goal was to see if the program was easy to use …

This study tested a new smartphone app that uses mindfulness exercises to help cancer survivors quit smoking. Twelve participants used the app and attended counseling sessions, then rated how much they liked the app and how helpful it was. The goal was to see if the app was easy …

This study tested a mobile health (mHealth) program to help people who had a stem cell transplant for blood cancer and still have trouble sleeping. About 30 survivors took part to see if the program was easy to use and helpful. The goal was to improve sleep quality and see if par…

This study tested whether a remote resistance training program is feasible and safe for people with advanced upper gastrointestinal cancer who are on chemotherapy. Twenty-two participants were asked to do strength exercises at home using video guidance. The study measured how man…

This study tested a smartphone app that uses augmented reality to help reduce cravings to smoke. 14 adults who recently quit smoking tried the app and rated how easy it was to use and how much they liked it. The goal was to see if the app could be a helpful tool for quitting smok…

This study looked at whether eating only during an 8-10 hour daytime window (without cutting calories) could improve how well immunotherapy works in people with advanced head and neck cancer. 29 patients were asked to follow this eating pattern, and researchers tracked their gut …

This study tested whether a pickleball program is practical and enjoyable for cancer survivors and their family or friends. The goal was to increase physical activity and improve overall wellness. 28 participants joined the program, which involved learning and playing pickleball …

This study tested whether a special online tool (eSNAP) plus a personal helper (Caregiver Navigator) could make family caregivers of brain cancer patients feel less stressed and burdened. About 296 caregivers and patients took part. The goal was to improve well-being by measuring…

This study tested a program to help lung cancer patients stop smoking and avoid starting again. 21 adults with lung cancer who smoked took part. The program included counseling, a web video, and support calls. The goal was to see if the program was easy to use and if patients lik…

This study tested a new mindfulness-based program to help people reduce alcohol use and quit smoking. 67 adults who smoked and drank alcohol participated. The goal was to see if the program was practical and liked by participants, and to measure how many quit smoking by the end o…

This study looked at whether using a person's DNA to pick an antidepressant works better than usual care for cancer patients with depression or anxiety. About 99 adults with cancer took part. Half got a DNA-guided choice of medication, and the other half got standard care. Resear…

This study tested whether a mathematical model could help doctors choose the best radiation schedule for people with HPV-positive throat cancer. The goal was to see if personalized dosing could shrink tumors faster than standard treatment. Fifty-five adults took part, and researc…

This study created a biobank—a collection of health data, saliva, and tumor tissue—from nearly 600 African American men in Florida who had prostate cancer. Researchers wanted to learn if smoking makes prostate cancer more aggressive. Participants filled out questionnaires and pro…

This study tested a smartphone app designed to educate and monitor patients with advanced kidney cancer (stage IV) who are starting combination immunotherapy. Twenty patients used the app, and researchers measured how acceptable and helpful it was, including its effect on quality…

This study tested whether an exercise program is practical for adults aged 65 and older with lymphoma, leukemia, or myeloma who are about to receive CAR T-cell immunotherapy. Twenty participants were enrolled to see if they would stick with the program and if it was safe. The goa…

This small study tested whether using a patient's tumor genetics to guide radiation dose could work for stage 2-3 non-small cell lung cancer. Only 3 people took part, and the main goal was to see if the approach was safe and feasible. The study is complete, but results are not ye…

This study looked at how men from different racial and ethnic backgrounds think about their genetic risk for prostate cancer. Researchers asked 100 men aged 40 and older who had never had prostate cancer to share their beliefs and provide a saliva sample. The goal was to understa…

This study tested a new device called the EnVisio SmartClip that helps doctors mark and find breast tumors during surgery. 50 people with breast cancer took part. The goal was to see if the SmartClip makes it easier for surgeons to locate and remove the right tissue.

This study gave educational materials about colorectal cancer and screening to 188 adults aged 45-75 in the Tampa Bay area. Researchers used surveys to measure changes in knowledge and screening intentions. The goal was to see if education encourages people to talk to their docto…

This study looked at how two different diets affect the bacteria in your gut. 115 Black and White adults from Alabama ate either the heart-healthy DASH diet or a typical American diet for 28 days. Researchers measured changes in gut bacteria and related health markers to see if t…

This study looked at 30 people with a rare and aggressive type of gut cancer called poorly-differentiated neuroendocrine carcinoma. Researchers used a special PET scan to see if the cancer cells have a certain marker (somatostatin receptor) that could be targeted by a future trea…

This study followed 60 adults with diffuse large B-cell lymphoma who were scheduled to receive a standard CAR T-cell therapy called axi-cel. Researchers measured changes in memory, attention, thinking skills, hand strength, and quality of life using questionnaires and tests. The …

This study looked at whether telling people about their genetic risk for melanoma (a serious skin cancer) changes how they protect themselves from the sun. Over 2,000 adults took part and reported their sun habits, like using sunscreen and wearing hats, before and after learning …

This study looked at whether teaching people about clinical trials helps them understand and feel more comfortable about taking part. Researchers gave 85 adults from the Tampa Bay area a short educational session and surveyed them before and after. The goal was to see if knowledg…