H. Lee Moffitt Cancer Center And Research Institute

This early-phase study tested whether giving a type of focused radiation (stereotactic radiosurgery) right after an immunotherapy drug (nivolumab) is safe and helps control breast cancer that has spread to the brain. Fourteen adults with up to 10 brain tumors took part. The main …

This early-phase study tested a new treatment called TBio-4101 for people with advanced melanoma that did not respond to standard therapies. The treatment uses a patient's own immune cells (TILs) that are selected and grown in a lab, then given back after chemotherapy to help fig…

This study tested a combination of two drugs, pembrolizumab and lenvatinib, in 20 people with advanced neuroendocrine tumors that had worsened despite prior treatments. The goal was to see if the combination could shrink tumors or slow their growth. Researchers measured response …

This early-phase study tested a combination of two targeted drugs, trametinib and ceritinib, in 27 adults with advanced melanoma that could not be removed by surgery and had stopped responding to standard treatments. The main goals were to find the safest dose and see if the comb…

This study tested a treatment for advanced melanoma that uses a patient's own immune cells. Doctors removed immune cells from the tumor, grew more of them in the lab, and then gave them back to the patient along with high-dose IL-2. The main goal was to see if this approach was f…

This study tested a combination of a targeted drug (vemurafenib), special immune cells (T-cells), and high-dose IL-2 in 17 people with advanced melanoma that had spread. The goal was to see if this approach could shrink or control tumors. While the treatment aims to fight the can…

This study tested a way to deliver strong chemotherapy drugs directly to the tumor through an artery in adults with malignant pleural mesothelioma that cannot be removed by surgery. The goal was to see if this treatment is safe and can control the disease. 34 participants receive…

This study tested a drug called nivolumab in 54 people with advanced biliary tract cancer that had not responded to previous treatments. Nivolumab helps the immune system attack cancer cells. The main goal was to see if tumors shrank or disappeared after four treatment cycles.

This study tested whether a pickleball program is practical and enjoyable for cancer survivors and their family members or friends. The goal was to increase physical activity and improve overall wellness. Researchers measured how many people joined, stuck with the program, and fo…

This study tested a mobile health (mHealth) program designed to help people who have had a blood stem cell transplant sleep better. About 30 survivors with sleep problems took part. The goal was to see if the program was easy to use and if people were satisfied with it.

This study tested a program called STRONG-PD that provides nutrition support from home for people with gastrointestinal cancer that has spread to the lining of the belly. Ten patients who had surgery and chemotherapy tried the program, which included remote guidance from a dietit…

This study gave educational materials about colorectal cancer and screening recommendations to 188 adults aged 45-75 in the Tampa Bay area. Researchers used surveys to see if the information increased people's knowledge and their plans to get screened. The goal was to understand …

This study tested whether a mathematical model could help doctors choose the best radiation schedule for people with HPV-positive throat cancer. The goal was to see if personalized dosing could shrink tumors faster. 55 patients took part, and the approach aimed to improve the num…

This study looked at how men from different racial and ethnic backgrounds think about their genetic risk for prostate cancer. Researchers asked 100 men aged 40 and older who had never had prostate cancer to share their beliefs and provide a saliva sample. The goal was to learn ab…

This study tested a new tool called the SmartClip that helps doctors precisely locate breast masses during surgery. 50 people with breast cancer took part. The goal was to see if the device helps surgeons find and remove the right tissue more accurately.

This early study tested whether giving a single dose of nivolumab with either ipilimumab or relatlimab before surgery is safe and possible in people with melanoma that has spread to the brain. Only one person took part, so the main goal was to see if the study could recruit enoug…

This study looked at whether an exercise program is practical for people aged 65 and older with blood cancers like lymphoma, leukemia, or myeloma who are about to receive CAR T-cell therapy. Twenty participants were enrolled to see if they would join, stick with, and safely compl…