New drug combo shows promise for Tough-to-Treat melanoma

NCT ID NCT03501368

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 21 times

Summary

This early-phase study tested a combination of two targeted drugs, trametinib and ceritinib, in 27 adults with advanced melanoma that could not be removed by surgery and had stopped responding to standard treatments. The main goals were to find the safest dose and see if the combination could shrink tumors. The study is complete, and results help guide future research on this drug pair.

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Contacts and locations

Locations

  • H. Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, 33612, United States

Conditions

Explore the condition pages connected to this study.