H. Lee Moffitt Cancer Center And Research Institute

This early-phase study tests a new treatment for people with advanced head and neck cancer that has spread or come back. The treatment uses a patient's own immune cells (called TILs) that are grown in a lab and given back along with an immunotherapy drug (pembrolizumab). The main…

This early-phase study tested a new way of giving three drugs (encorafenib, binimetinib, and nivolumab) to people with advanced BRAF-mutant melanoma. Instead of taking the drugs every day, participants followed an on/off schedule to see if it could control the cancer while reduci…

This early-phase study tested a combination of two drugs—romidepsin and durvalumab—given directly into the bladder for people with muscle-invasive bladder cancer who cannot receive standard chemotherapy. The goal was to find the safest dose and see if the treatment could shrink o…

This early-phase trial tests whether a single infusion of specially grown donor immune cells (γδ T-cells) can help prevent acute myeloid leukemia from returning in 20 adults who have already had a stem cell transplant. The main goals are to find the safest dose and see how well i…

This early-phase study tests a new drug called XL888 added to two standard melanoma drugs (vemurafenib and cobimetinib) for people with advanced BRAF-mutated melanoma that cannot be removed by surgery. The main goal is to find the safest dose of XL888 and see how well the combina…

This early-phase study tested whether taking the drug abiraterone on an on-and-off schedule could help men with advanced prostate cancer respond to the drug for a longer time. The study enrolled 19 men whose cancer had stopped responding to standard hormone therapy. Researchers m…

This study compares an automated video-based smoking cessation program to standard treatment for people living with HIV. Researchers want to see if the automated approach helps more participants quit smoking for good. The study enrolled 638 HIV-positive adults who smoke at least …

This study tests whether adding targeted radiation (SBRT) to an immunotherapy drug (atezolizumab) can shrink tumors better than the drug alone in people with cervical cancer that has come back or spread. About 21 adults with advanced cervical, vaginal, or vulvar cancer are partic…

This study looks at whether a combination of two drugs works better than one drug alone to keep multiple myeloma from coming back after a stem cell transplant. About 69 adults with newly diagnosed myeloma will receive either a single drug or a two-drug combo as maintenance therap…

This study tests a new approach to help people who have had cervical cancer or high-grade cervical dysplasia quit smoking. Participants receive phone counseling and personalized text messages to support quitting. The goal is to see if this method helps more people stay smoke-free…

This early-phase study tests whether combining phototherapy (light treatment) with the drug mogamulizumab can help control early-stage mycosis fungoides, a rare type of skin lymphoma. About 20 adults with stage IA-IIA disease will receive both treatments together. The main goal i…

This study tests a new way of giving two approved drugs (pembrolizumab and axitinib) to people with advanced kidney cancer. Instead of a fixed schedule, the dose and timing are adjusted based on how well the tumor responds. The goal is to keep the cancer under control while possi…

This study tests a two-step treatment plan for men with high-risk metastatic prostate cancer that still responds to hormone therapy. First, patients receive hormone therapy plus a newer hormone-blocking drug, followed by chemotherapy. The goal is to see if this sequence improves …

This study tests whether adding ruxolitinib to a standard tyrosine kinase inhibitor (TKI) can help people with chronic myeloid leukemia (CML) achieve a lasting remission after stopping all treatment. Participants are adults with CML who previously tried to stop their TKI but rela…

This study tests a drug called fedratinib in 25 adults with rare blood cancers (MDS/MPN and chronic neutrophilic leukemia). The goal is to see if the drug can shrink the spleen and improve blood counts. Fedratinib is taken as a pill and aims to control the disease, not cure it.

This early-phase study tests whether 30 minutes of moderate exercise (like arm cycling or treadmill) right before each immunotherapy session can improve treatment for skin cancers such as melanoma. About 22 adults who are starting standard immunotherapy will participate. The main…

This study tests two treatments—nivolumab alone or with azacitidine—in people whose osteosarcoma (a type of bone cancer) has come back and can be surgically removed. The goal is to see if these drugs are safe and help keep the cancer from returning after surgery. About 21 adults …

This study tests giving focused radiation before surgery to remove brain tumors that have spread from other cancers. The goal is to see if this approach helps keep the tumors from returning longer than the usual treatment. About 49 adults with at least one brain tumor will take p…

This early-stage study tests whether giving the drug cemiplimab before surgery is safe for people with Merkel cell carcinoma or cutaneous squamous cell carcinoma. About 36 adults with stage I-II skin cancer will receive the drug, then have their tumor removed. Researchers will tr…

This early-stage trial tests whether adding canakinumab to darbepoetin alfa can safely improve red blood cell counts in people with lower-risk myelodysplastic syndromes (MDS) who no longer respond to standard erythropoietin-stimulating agents. The study involves 13 participants a…

This study tests whether a natural substance called delta-tocotrienol (a form of vitamin E) can prevent pancreatic cysts (IPMN) from growing or turning into cancer. About 4 adults with low-risk IPMN are randomly assigned to receive either the supplement or a placebo. The goal is …

This study tests whether a practical diet and exercise program can help people with certain pancreatic cysts (IPMNs) lower their risk of developing pancreatic cancer. Twenty-four adults with large cysts and excess belly fat will follow a 6-month program of physical activity and n…

This study tests two different vaccines in people who have already been treated for HER-2 positive breast cancer but still had some cancer left after chemotherapy and surgery. The goal is to see if the vaccines are safe and can help prevent the cancer from coming back. About 119 …

This study tests a program that gives pancreatic cancer patients extra nutrition support from dietitians through remote visits and a Fitbit to track eating. The goal is to see if the program is practical and liked by patients, and to help prevent weight loss and malnutrition duri…

This study looks at tiny plastic particles, called microplastics, in the lungs of 119 people. Researchers will compare the amount and types of microplastics found in patients with and without lung cancer. The goal is to see if there is a connection between microplastic pollution …

This study looks at the lifestyle habits and quality of life of young adults who had cancer between ages 19 and 29. Researchers will use surveys and fitness trackers to understand current behaviors. The goal is to create a personalized diet and exercise program to help survivors …

This study looks at 500 men with prostate cancer to find non-invasive biomarkers—like substances in blood or urine—that can show if the disease is getting worse. Participants continue their normal care, including biopsies and scans, and also give extra blood and urine samples. Th…