H. Lee Moffitt Cancer Center And Research Institute

This study aims to increase HPV vaccination rates among 11-17 year olds by using strategies that involve parents, healthcare providers, and health centers. Researchers will work with 8 community health centers in Florida to encourage teens to start and complete the HPV vaccine se…

This early-stage trial tests a new dendritic cell vaccine for people with breast cancer that has spread to the lining of the brain and spinal cord (leptomeningeal disease). The vaccine is designed to train the immune system to attack cancer cells. The main goal is to find the saf…

This study compares an automated video-based smoking cessation program to standard treatment for people living with HIV. The goal is to see if the automated approach leads to more long-term quit rates. 638 participants who smoke at least 5 cigarettes daily and are willing to quit…

This study tests a drug called ruxolitinib in 29 adults with chronic myelomonocytic leukemia (CMML), a rare blood cancer. The goal is to see if the drug can improve blood counts, shrink the cancer, or slow its progression to a more aggressive leukemia. Participants take the drug …

This study tests whether a program combining phone counseling and personalized text messages can help 360 cervical cancer survivors in Florida quit smoking better than standard quitline services. Participants must have a history of cervical cancer or high-grade cervical dysplasia…

This early-phase study tests a combination of two drugs—romidepsin and durvalumab—given directly into the bladder for people with muscle-invasive bladder cancer who cannot receive standard chemotherapy. The goal is to see if the combination is safe and can shrink or eliminate tum…

This study tests a drug called DFMO combined with the immunotherapy pembrolizumab in people with advanced non-small cell lung cancer (NSCLC). The goal is to find a safe dose and see if the combination helps shrink tumors. About 45 adults with measurable disease will take part.

This early-stage trial tests two drugs together—canakinumab and darbepoetin alfa—in people with a lower-risk form of myelodysplastic syndromes (MDS) whose previous treatment stopped working. The goal is to see if the combination is safe and can help the body make more red blood c…

This study tests a combination of three drugs (ipilimumab, nivolumab, and sacituzumab govitecan) as a first treatment for people with advanced bladder cancer who cannot take standard chemotherapy. About 46 adults will participate to find the best dose and see how well the drugs s…

This study tests whether combining two drugs, pembrolizumab and vorinostat, can help control advanced non-small cell lung cancer. About 120 adults with stage IV lung cancer will receive either the combination or pembrolizumab alone. The goal is to see if the combination is safe a…

This study tested whether taking the drug abiraterone on an on-and-off schedule could help it work longer for men with advanced prostate cancer that no longer responds to hormone therapy. Nineteen men whose cancer had already responded to standard daily abiraterone were enrolled.…

This study tests a combination of the experimental drug neratinib plus standard chemotherapy, trastuzumab, and pembrolizumab in people with HER2-positive gastroesophageal cancer. The goal is to see how well the treatment shrinks tumors and controls the disease. About 8 adults wit…

This study tests two drugs, lenvatinib and pembrolizumab, given before surgery to people with Merkel cell carcinoma, a rare skin cancer. The goal is to shrink tumors and improve outcomes. 26 adults with stage II to IV cancer are participating. The main measure is how many patient…

This study tests whether adding ruxolitinib to standard tyrosine kinase inhibitor (TKI) therapy helps people with chronic myeloid leukemia (CML) stay in remission after stopping their medication. It includes 24 adults who previously tried and failed to stop TKI therapy. Participa…

This early-phase trial tests whether a single infusion of specially grown donor immune cells (γδ T-cells) can help prevent acute myeloid leukemia from coming back in patients who had a stem cell transplant. About 20 adults aged 18-75 at high risk of relapse will receive increasin…

This study tests whether giving two drugs (cetuximab and cemiplimab) before surgery can help shrink tumors in people with head and neck squamous cell carcinoma. About 22 adults will receive the combination before their planned surgery. The main goal is to see how many patients ha…

This early-stage trial tests a new way to treat high-grade bladder cancer that hasn't spread into the muscle. Doctors take immune cells from the patient's own tumor, grow them in a lab, and put them back into the bladder. The goal is to see if this is safe and can shrink or elimi…

This study tests a personalized approach to treating advanced kidney cancer by adjusting doses of two drugs (pembrolizumab and axitinib) based on how well the tumor responds. It involves 75 adults with clear cell renal cell carcinoma that cannot be removed by surgery. The goal is…

This early-phase study tested a new way of giving three drugs (encorafenib, binimetinib, and nivolumab) to people with advanced BRAF-mutant melanoma. Instead of taking the drugs every day, participants followed an on/off schedule to see if it could control the cancer while reduci…

This study tested whether adding stress management techniques to a standard weight loss program helps Black women with obesity lose more weight. Over 300 women participated, and researchers measured weight changes at 4 and 12 months. The goal is to find a culturally relevant appr…

This study tests a drug called luspatercept in 6 adults with lower-risk myelodysplastic syndromes (MDS) or related blood cancers who have anemia. The goal is to see if the drug can reduce or eliminate the need for regular blood transfusions. Participants receive luspatercept plus…

This study tests whether a daily dose of green tea catechins (a natural compound in green tea) can prevent prostate cancer from getting worse in men who are monitoring their low- to intermediate-risk cancer without immediate treatment. Over two years, 115 men will receive either …

This early-phase study tests a combination of two drugs, ceritinib and docetaxel, in people with advanced non-small cell lung cancer that does not have certain genetic markers (ALK-negative, EGFR wild-type). The main goal is to find the safest dose and see if the combination can …

This early-phase study tests whether 30 minutes of moderate exercise (like walking or cycling) right before standard immunotherapy can improve treatment for certain skin cancers (melanoma, squamous cell carcinoma, Merkel cell carcinoma). About 22 adults will exercise before each …

This study tests giving focused radiation before surgery to remove brain tumors, aiming to delay cancer regrowth. About 49 adults with solid tumors that have spread to the brain will receive this treatment. The goal is to see if this approach works better than the current standar…

This study tests whether adding targeted radiation (SBRT) to the immunotherapy drug atezolizumab can shrink tumors better than atezolizumab alone in people with cervical cancer that has come back or spread. About 21 adults with advanced cervical cancer are participating. The goal…

This study tests whether using MRI scans during radiation therapy can help doctors adjust the treatment in real time for people with locally advanced rectal cancer. The goal is to improve the chance of a complete response, meaning no cancer remains after treatment. The trial invo…

This study tests whether radiation therapy followed by two targeted drugs (trastuzumab and pertuzumab) given directly into the spinal fluid is safe and helps people with HER2+ breast cancer that has spread to the lining of the brain and spinal cord live longer. About 33 adults wi…

This study tests a new approach called adaptive androgen deprivation therapy for men with stage IV prostate cancer that still responds to hormone treatment. The goal is to see if adjusting hormone therapy based on PSA levels can keep the cancer under control while reducing side e…

This early-phase trial tests whether adding chest radiation followed by immunotherapy drugs (durvalumab alone or with tremelimumab or olaparib) can help control extensive-stage small cell lung cancer after initial chemotherapy. About 25 adults whose cancer did not worsen after fi…

This study tests whether adding a precise form of radiation (SBRT) to a two-drug immunotherapy combination (nivolumab and ipilimumab) works better than the drugs alone for people with advanced Merkel cell carcinoma that has spread. The trial enrolls 50 adults whose cancer has ret…

This study tests a new way of giving hormone therapy (androgen deprivation) along with chemotherapy (docetaxel) for men with stage IV prostate cancer that still responds to hormones. The goal is to see if this approach can keep the cancer sensitive to hormone treatment for at lea…

This study tests four different chemotherapy schedules in children and adults with a rare, aggressive muscle cancer that has spread. Participants choose from a first-strike approach, a first-strike followed by maintenance, an adaptive schedule, or standard chemo. The goal is to s…

This study tests whether two drugs, binimetinib and belinostat, can shrink or stop tumors in people with metastatic uveal melanoma, a rare eye cancer that has spread. About 7 adults with good overall health and measurable tumors are taking part. The main goal is to see how many p…

This pilot study aimed to see if combining phototherapy (light treatment) with the drug POTELIGEO (mogamulizumab) is safe and effective for people with early-stage mycosis fungoides, a type of skin lymphoma. The study planned to enroll 20 adults with stage IA-IIA disease. However…

This study tests whether combining three drugs—nivolumab, ipilimumab, and nintedanib—can shrink tumors in people with advanced non-small cell lung cancer that cannot be cured. About 66 adults with no other treatment options will take part. The goal is to find the safest dose and …

This study tests whether adding the immunotherapy drug nivolumab to standard radiation and hormone therapy is safe and effective for men with a very aggressive type of prostate cancer (Gleason grade group 5). About 44 men will receive the combination treatment. The goal is to see…

This study looks at whether giving a pneumococcal (pneumonia) vaccine before and after CAR T-cell therapy helps lymphoma patients build stronger immunity. About 26 adults with certain types of B-cell lymphoma will receive the vaccine at specific times around their CAR T-cell trea…

This study tests whether a combination of Lovaza (a fish oil drug) and Curcumin C3 Complex (from turmeric root) can reduce the size of lung nodules in current and former smokers aged 55 and older. The goal is to lower the risk of lung cancer. The trial involves 19 participants an…

This study tests a drug called fedratinib in 25 adults with rare blood cancers (MDS/MPN and chronic neutrophilic leukemia). The goal is to see if the drug can shrink enlarged spleens and improve blood counts. Fedratinib is taken as a pill and works by blocking certain signals tha…

This early-phase study tests a new treatment for people with advanced head and neck cancer that has spread or come back. The treatment uses a patient's own immune cells (called TILs) that are grown in a lab and given back along with the drug pembrolizumab, with or without chemoth…

This study looks at whether a combination of two drugs works better than one drug alone to keep multiple myeloma from coming back after a stem cell transplant. About 69 adults who had a transplant as their first treatment are being followed for up to two years. The goal is to see…

This study tests a personalized treatment plan using the drug daratumumab for adults aged 65 and older who have newly diagnosed multiple myeloma and cannot tolerate standard high-dose chemotherapy. The goal is to see how well the treatment controls the disease by measuring tumor …

This study tests a two-step treatment plan for men with high-risk metastatic prostate cancer. First, patients receive hormone therapy plus a newer drug, followed by chemotherapy. The goal is to improve survival by attacking the cancer in a sequence inspired by how species go exti…

This early-phase study tests a new drug called XL888 added to two standard treatments (vemurafenib and cobimetinib) for people with advanced BRAF-mutated melanoma that cannot be removed by surgery. The main goal is to find the safest dose of XL888 and see how well the combination…

This early-phase study tests a virus-based drug called CG0070 in 20 people with intermediate-risk bladder cancer that has not invaded the muscle. After surgery to remove visible tumors, patients receive CG0070 to see if it is safe and can help prevent the cancer from coming back.…

This study is for people whose osteosarcoma (a type of bone cancer) has come back and can be surgically removed. It tests two drugs: nivolumab (an immunotherapy) alone or with azacitidine (a chemotherapy-like drug). The goal is to see if these treatments are safe and can keep the…

This study tests a health workshop for Latino parents in rural Florida who have children aged 6 to 12. The workshop teaches healthy eating, physical activity, and sun protection to reduce cancer risk. Researchers will also ask participants for feedback to improve the program for …

This study tests two different vaccines designed to prevent HER-2 positive breast cancer from coming back in people who have already completed initial treatment. About 119 participants who had surgery after chemotherapy will receive one of the two vaccines, followed by booster sh…

This study tests whether a form of vitamin E called delta-tocotrienol can prevent pancreatic cysts (IPMN) from getting worse. Four adults with IPMN that is being watched but not yet dangerous will receive either the supplement or a placebo. The goal is to see if the treatment can…

This study tests whether a practical diet and exercise program can help people with certain pancreatic cysts lower their risk of developing pancreatic cancer. Twenty-four adults with a type of pancreatic cyst called IPMN (larger than 15 mm) and who are overweight will follow a 6-…

This study tests a program that gives pancreatic cancer patients extra nutrition support from a dietitian through remote visits. The goal is to see if the program is practical and helpful for patients receiving chemotherapy. About 80 adults with advanced pancreatic cancer will ta…

This study tests a program that gives nutrition support to people with gastroesophageal cancer through a phone app and dietitian visits. The goal is to see if the program is easy to use and helpful for patients during chemotherapy and radiation. About 23 adults with advanced canc…

This study looks at whether eating fermented foods (like yogurt, kimchi, and sauerkraut) can help people with rectal or lung cancer respond better to their standard treatments. About 39 patients will either add these foods to their diet or continue eating normally. Researchers wi…

This study looks at whether a mindfulness-based stress management program can lower the stress and burden felt by caregivers of patients receiving a stem cell transplant (allogeneic HCT). About 505 caregivers and patients are taking part. The program uses a smartphone app to teac…

This study is testing a procedure called prostatic artery embolization (PAE) in 17 men with early-stage prostate cancer who also have trouble urinating. The goal is to see if PAE can reduce urinary symptoms before they start radiation therapy. Participants will have their symptom…

This study looks at whether a remote nutrition coaching program is practical and helpful for people with pancreatic cancer who are undergoing chemotherapy. About 40 participants will receive coaching and monitoring over 12 weeks. The goal is to see if patients find the program us…

This study looks at whether giving cancer survivors free fruits, vegetables, and cooking lessons can help them eat healthier. Eleven participants will take part in a 12-week program at a YMCA, receiving food bundles, recipes, and hands-on cooking demonstrations. The goal is to se…

This study is collecting fluid from the lungs of 119 patients (some with lung cancer, some without) to measure how many microplastic particles are present. Researchers want to see if people with lung cancer have more microplastics in their lungs. The goal is to understand if micr…

This study looks at a new website designed to help young adults (ages 18-39) who have had cancer understand how their treatment might affect their ability to have children and the genetic risks for their future kids. Sixteen participants from Moffitt Cancer Center will try the to…

This study is creating a biobank—a collection of blood, tissue, and other samples—from 500 people with or suspected of having pancreatic cancer. The goal is to learn why some groups are affected more than others and to find ways to personalize care. Participants donate samples an…

This study looks at the lifestyle habits and quality of life of young adults who had cancer between ages 19 and 29. Researchers will use surveys and fitness trackers to understand current behaviors and then create a personalized diet and exercise program. The goal is to help surv…

This study looks at how quality of life differs among older adults (60+) newly diagnosed with acute myeloid leukemia (AML) who receive either intensive or non-intensive chemotherapy. Researchers aim to build a decision-making model that helps patients and doctors choose treatment…

This study is creating a large database of people at high risk for pancreatic cancer, including those with cysts, genetic conditions, or other risk factors. The goal is to track their health over time to find better ways to detect the disease early or even prevent it. About 317 p…

This study involves 500 men with prostate cancer to see if non-invasive biomarkers (found in blood and urine) can help track disease progression. Participants will undergo standard care, including biopsies and imaging, plus extra fluid collection. The goal is to improve monitorin…

This study looks at whether a tumor test called Decipher can predict aggressive prostate cancer as accurately in African-American men as in other men. Researchers will follow 240 men with prostate cancer to see if the test helps doctors choose the right treatment. The goal is to …

This study tests whether a personalized diet and exercise program is practical for people who have had head and neck cancers (like mouth or throat cancer). Researchers will enroll 40 survivors to see if they can stick with the program and find it helpful. The goal is to learn if …

This study looks at whether a home-based exercise program is practical and safe for people aged 65 and older who are waiting for liver or bile duct cancer surgery. About 25 participants will do supervised exercise sessions and be tracked for how many join, stick with it, and repo…

This study looks at whether a special program called CARES-REACH can help more people in rural areas get screened for colorectal cancer. The program focuses on using a simple at-home stool test (FIT). Researchers will track how many patients complete the test and see what factors…

This pilot study aimed to compare two ways of helping patients breathe during anesthesia for robotic gynecologic or genitourinary cancer surgery. The goal was to see if a newer method (APRV) improves lung function compared to the standard method (CMV). The study was withdrawn bef…