Can routine brain scans catch hidden cancer spread in stage IV breast cancer?

NCT ID NCT05115474

Recruiting now Diagnosis Sponsor: H. Lee Moffitt Cancer Center and Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether routine brain MRIs can find brain metastases in stage IV breast cancer patients who have no neurological symptoms. Researchers will scan 170 participants at the start and again at 6 months or when their cancer first progresses. The goal is to see how often brain metastases occur in different breast cancer subtypes and whether early detection is possible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Magnetic Resonance Imaging (MRI)
What this could lead to: If successful, this could show that regular brain MRIs help find brain metastases earlier in stage IV breast cancer patients, potentially guiding treatment decisions.
What could go wrong: This is a phase 2 study with only 170 participants, so results may not apply to all patients. It is not testing a treatment, only screening, so it may not improve survival or quality of life.

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Conditions

The condition(s) this trial relates to.

breast carcinoma breast neoplasm HER2 positive breast carcinoma hormone receptor-positive breast cancer triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HER2-POSITIVE BREAST CANCER HORMONE RECEPTOR POSITIVE BREAST CANCER TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

Locations

Moffitt Cancer Center
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33612, United States
Morton Plant Mease- Baycare
RECRUITING

Clearwater, Florida, 33756, United States

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