New hope for tough AML: targeted pill plus chemo combo tested
NCT ID NCT06660368
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding the targeted drug venetoclax to a standard chemotherapy regimen (CLAG-M) can improve outcomes for adults with relapsed or refractory acute myeloid leukemia (AML). About 52 participants will be randomly assigned to receive either CLAG-M alone or CLAG-M plus venetoclax. The main goal is to see if the combination leads to a deeper remission (negative for minimal residual disease) and longer event-free survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Venetoclax (a targeted cancer pill) plus a chemotherapy combination called CLAG-M (cladribine, cytarabine, mitoxantrone, and a growth factor G-CSF)
- What this could lead to
- If successful, this combination could offer a more effective treatment option for people with hard-to-treat AML, potentially leading to longer remission and better outcomes.
- What could go wrong
- This is a small, early-phase (Phase 2) study with only 52 participants. The added drug may increase side effects, and results may not apply to all patients. It is not a cure and long-term benefits are uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dana-Farber Cancer Institute
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
-
Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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