ORAL CAVITY SQUAMOUS CELL CARCINOMA
Clinical trials for ORAL CAVITY SQUAMOUS CELL CARCINOMA explained in plain language.
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Less neck surgery may spare shoulder function in oral cancer patients
Disease control Recruiting nowThis study tests whether a less invasive surgery called sentinel lymph node biopsy can replace standard neck dissection for early-stage oral cavity cancer. About 686 patients will be randomly assigned to one of the two procedures. The goal is to see if the gentler approach mainta…
Matched conditions: ORAL CAVITY SQUAMOUS CELL CARCINOMA
Phase: PHASE2, PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Could a Two-Drug punch before surgery shrink head & neck tumors?
Disease control Recruiting nowThis study tests whether adding an experimental drug (CDX-1140) to a standard immunotherapy (cemiplimab) before surgery can shrink advanced head and neck cancers more than the immunotherapy alone. About 44 people with stage III-IV head and neck cancer will receive either the comb…
Matched conditions: ORAL CAVITY SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Oral cancer patients may avoid unnecessary radiation to the neck
Disease control Recruiting nowThis study tests whether it is safe to skip radiation to the lymph nodes in the neck after surgery for early-stage oral cancer. About 396 adults aged 18-70 with certain high-risk features will be randomly assigned to receive or not receive this radiation. The goal is to see if sk…
Matched conditions: ORAL CAVITY SQUAMOUS CELL CARCINOMA
Phase: PHASE2, PHASE3 • Sponsor: All India Institute of Medical Sciences • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Could less radiation be safer? new trial aims to cut side effects after head and neck cancer surgery
Disease control Recruiting nowThis phase II trial tests whether a personalized, reduced-volume radiation plan can safely lower side effects after surgery for head and neck cancer. About 50 patients will receive radiation only to high-risk areas, skipping some traditionally treated zones. The goal is to see if…
Matched conditions: ORAL CAVITY SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: Olgun Elicin • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Could a food preservative help fight oral cancer?
Disease control Recruiting nowThis study tests whether nisin, a natural preservative found in some foods, can safely change the bacteria in the mouths of people with oral cavity squamous cell carcinoma. About 40 patients will take nisin before and after their standard surgery. The goal is to find a safe dose …
Matched conditions: ORAL CAVITY SQUAMOUS CELL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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New program aims to speed up radiation for head and neck cancer patients
Disease control Recruiting nowThis trial tests a program called ENDURE that helps head and neck cancer patients start radiation therapy within 6 weeks after surgery. The program provides education, social support, and better coordination among doctors. Researchers will compare it to usual care in 532 adults w…
Matched conditions: ORAL CAVITY SQUAMOUS CELL CARCINOMA
Phase: NA • Sponsor: Medical University of South Carolina • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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New skin flap could reduce surgery side effects for head and neck cancer patients
Disease control Recruiting nowThis study tests a new surgical technique using a thin skin flap from the groin area to rebuild the mouth or throat after cancer removal. The goal is to see if it causes fewer problems at the donor site compared to standard flaps. Forty adults with head and neck cancer will be fo…
Matched conditions: ORAL CAVITY SQUAMOUS CELL CARCINOMA
Phase: NA • Sponsor: Institut Claudius Regaud • Aim: Disease control
Last updated Jun 26, 2026 17:27 UTC
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New drug aims to ease painful mouth sores for head and neck cancer patients
Symptom relief Recruiting nowThis phase II trial tests whether adding BMX-001 to standard symptom management can reduce severe mouth sores in head and neck cancer patients receiving chemoradiation. About 98 participants will receive either BMX-001 or a placebo alongside usual care. The goal is to see if BMX-…
Matched conditions: ORAL CAVITY SQUAMOUS CELL CARCINOMA
Phase: PHASE2 • Sponsor: NRG Oncology • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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Can a constipation drug help head and neck cancer patients before surgery?
Symptom relief Recruiting nowThis study tests whether a drug called methylnaltrexone is safe for people with head and neck cancer when taken for two weeks before their surgery. The drug is already used for constipation, but researchers want to see if it can be given safely in this setting. About 25 adults wi…
Matched conditions: ORAL CAVITY SQUAMOUS CELL CARCINOMA
Phase: PHASE4 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Remote hearing tests could save cancer Patients' hearing
Knowledge-focused Recruiting nowThis study tests whether offering hearing tests close to home or remotely increases how many head and neck cancer patients get their hearing checked during treatment. Many patients on cisplatin chemotherapy or radiation near the ear can lose hearing, but not all complete recommen…
Matched conditions: ORAL CAVITY SQUAMOUS CELL CARCINOMA
Phase: NA • Sponsor: Emory University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Can immune markers predict success of docetaxel chemoradiotherapy?
Knowledge-focused Recruiting nowThis study looks at immune markers in tumor tissue, saliva, stool, and blood from 250 head and neck cancer patients who cannot receive cisplatin chemotherapy. Researchers want to see if these markers can predict how well patients respond to chemoradiotherapy with docetaxel. The g…
Matched conditions: ORAL CAVITY SQUAMOUS CELL CARCINOMA
Sponsor: University of Erlangen-Nürnberg Medical School • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Blood test may tell which oral cancer patients need more chemo
Knowledge-focused Recruiting nowThis study looks at whether a blood test that finds circulating tumor cells (CTCs) can help decide if oral cancer patients need extra chemotherapy after standard treatment. About 100 patients who have completed surgery and chemoradiotherapy will be tested. If their CTC count is h…
Matched conditions: ORAL CAVITY SQUAMOUS CELL CARCINOMA
Phase: NA • Sponsor: Chang Gung Memorial Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC