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Less neck surgery may be just as effective for oral cancer with one affected node

NCT ID NCT07717307

Disease control Sponsor: Kolhapur Cancer Centre - Cancer Centers of America Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Aug 05, 2026 · Updated 3 times

Summary

This trial tests whether removing fewer lymph nodes from the neck (selective dissection, levels I-IV) works as well as the standard more extensive removal (modified dissection, levels I-V) in people with oral cancer that has spread to a single lymph node. The goal is to see if the less invasive surgery can control cancer recurrence just as well while improving shoulder function and quality of life. About 80 participants will be randomly assigned to one of the two surgeries and followed for three years.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Selective neck dissection (levels I-IV) or modified neck dissection (levels I-V) surgery
What this could lead to
If successful, this trial could show that a less extensive neck surgery is just as effective at controlling cancer while causing fewer side effects and better quality of life.
What could go wrong
This is a relatively small, single-center trial, and results may not apply to all patients. The less extensive surgery might not control cancer as well in some cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Apr 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologically proven squamous cell carcinoma of oral cavity will be included * Clinical stage T1-T4, N1, M0 * cN1 neck on clinical examination and imaging (CT/MRI) * Single node which is FNAC proven without any other significant nodes. * Patients with ASA grade II and I. * Understands the protocol and able to give informed consent. Exclusion Criteria: * Recurrent cases * Multiple significant nodes * Nodes clinical/radiological with ENE * Single metastatic node at level III/IV/V * Single metastatic node with other suspicious nodes * Patients with a history of head and neck radiation therapy treatment * Previous history of any malignancy

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Conditions

The condition(s) this trial relates to.

Head and Neck Neoplasms Mouth Neoplasms oral cavity squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oral cavity squamous cell carcinoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kolhapur Cancer Centre

    RECRUITING

    Kolhāpur, Maharashtra, 416004, India

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