SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Clinical trials for SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK explained in plain language.
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MRI-Guided radiation boost shows promise in head and neck cancer trial
Disease control OngoingThis study tests whether giving an extra dose of radiation to oxygen-poor (hypoxic) areas of head and neck tumors can improve treatment response. About 91 adults with advanced squamous cell cancer of the throat or voice box will receive standard chemo-radiation with or without th…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: Regina Elena Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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Could a simple shot replace IV drips for some cancer patients?
Disease control OngoingThis early-stage trial is testing whether amivantamab, a drug that targets specific proteins on cancer cells, can be given as a shot under the skin instead of through an IV. About 158 adults with advanced solid tumors (like lung or head and neck cancers) will receive different do…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: Janssen Research & Development, LLC • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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New hope for advanced cancers: JANX008 enters human testing
Disease control OngoingThis early-phase study tests a new drug called JANX008 in about 130 adults with advanced solid tumors, including lung, kidney, head and neck, colorectal, pancreatic, and breast cancers. The main goal is to check safety and find the right dose. Participants must have tried all sta…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: Janux Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New hope for head and neck cancer: drug combo trial underway
Disease control OngoingThis phase 3 trial tests whether adding monalizumab to the standard drug cetuximab helps people with recurrent or metastatic head and neck cancer live longer. The study includes 370 adults who have already tried an immune checkpoint inhibitor and platinum-based chemotherapy. Part…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE3 • Sponsor: AstraZeneca • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New antibody drug takes on advanced cancers in first human trial
Disease control OngoingThis early-phase trial is testing a new drug called NTX-1088, which targets a protein on cancer cells, either alone or combined with the immunotherapy pembrolizumab. The study involves 90 people with advanced solid tumors that have spread or cannot be removed. The main goals are …
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: Nectin Therapeutics Ltd • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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New drug cocktail aims to shrink head and neck tumors before surgery
Disease control ENROLLING_BY_INVITATIONThis phase 2 trial is testing whether combining two drugs, pertuzumab and lenvatinib, can shrink tumors before surgery in people with advanced head and neck cancer. About 30 participants will receive 2-4 cycles of the drug combination, then undergo surgery. The main goal is to se…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: Zhejiang Provincial People's Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New drug combo tested for tough cancers
Disease control OngoingThis early-stage trial tests a new drug called BMS-986484, alone or with another drug (nivolumab), in people with advanced solid tumors like lung, colon, pancreatic, stomach, and head/neck cancers. The main goal is to check safety and find the right dose. About 213 participants w…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: Bristol-Myers Squibb • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New antibody combo shows promise in early cancer trial
Disease control OngoingThis trial tests a new antibody called acasunlimab, alone or with other cancer drugs, in people with advanced solid tumors that have not responded to standard treatments. The study has two parts: first to find safe doses, then to see how well those doses work. About 429 participa…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1, PHASE2 • Sponsor: Genmab • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Could a Chemo-Immunotherapy cocktail spare head and neck cancer patients from radiation?
Disease control OngoingThis phase 2 trial tests a combination of two chemotherapy drugs (carboplatin and nab-paclitaxel) plus an immunotherapy drug (durvalumab) given before surgery for people with locally advanced head and neck cancer. The goal is to shrink or eliminate the tumor so that radiation—whi…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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Immunotherapy drug may delay cancer's return after surgery
Disease control OngoingThis study tests whether the immunotherapy drug pembrolizumab can help people with head and neck cancer that has come back after initial treatment. After surgery to remove the recurrent tumor, participants receive pembrolizumab to see if it extends the time before the cancer retu…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: Assuntina G. Sacco, MD • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Can a targeted antibody boost Radiation's power against head and neck cancer?
Disease control OngoingThis phase III trial studies whether adding the drug cetuximab to modern radiation therapy improves survival for people with advanced head and neck cancer that has been surgically removed. About 700 participants received either radiation alone or radiation plus cetuximab. The stu…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE3 • Sponsor: Radiation Therapy Oncology Group • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Weekly vs. Every-3-Week cisplatin: which is safer for head and neck cancer?
Disease control OngoingThis phase 2 trial tests whether giving cisplatin chemotherapy weekly alongside radiation causes fewer severe side effects than the standard every-3-week schedule in people with head and neck cancer. About 80 participants will receive one of the two schedules. The study also look…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE2 • Sponsor: Susanne Arnold • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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New MRI-Guided radiation aims to spare cancer patients from chronic dry mouth
Symptom relief OngoingThis study tests a new type of radiotherapy that uses daily MRI scans to precisely target head and neck cancer while avoiding the saliva glands. The goal is to reduce severe dry mouth, a common and lasting side effect. Forty-nine patients will receive this adaptive treatment and …
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: NA • Sponsor: Panagiotis Balermpas • Aim: Symptom relief
Last updated Jun 27, 2026 12:25 UTC
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Which tube feeding method works best for head and neck cancer patients?
Symptom relief TerminatedThis study aimed to compare three tube feeding methods—bolus, gravity, and pump—in 60 head and neck cancer patients undergoing chemoradiation. The goal was to see which method leads to the least weight loss and best tolerance. However, the trial was withdrawn before any patients …
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: NA • Sponsor: Baylor Research Institute • Aim: Symptom relief
Last updated Jun 27, 2026 12:24 UTC
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AI reads scans to forecast cancer treatment success
Knowledge-focused OngoingThis study tests whether artificial intelligence (AI) can analyze medical scans (CT, MRI, PET) to predict how well head and neck cancer patients will respond to radiation therapy and whether they will have side effects. The goal is to personalize treatment for better outcomes. Ab…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: NA • Sponsor: Istituto Clinico Humanitas • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:26 UTC
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Can injecting immunotherapy directly into tumors boost the body's fight against head and neck cancer?
Knowledge-focused OngoingThis study is for 18 adults with head and neck cancer who are already scheduled for surgery. Researchers want to see if it is safe and possible to inject the drug ipilimumab directly into the tumor a few weeks before the operation. The main goal is to check if this approach delay…
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Phase: PHASE1 • Sponsor: Providence Health & Services • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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New study tracks Cancer's genetic secrets during therapy
Knowledge-focused OngoingThis research study looks at how certain cancers (head and neck, esophagus, and anal canal) change at the genetic and immune level when patients receive chemotherapy or immunotherapy. About 39 people with advanced cancer will provide blood samples and tumor tissue over time. The …
Matched conditions: SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Sponsor: University Health Network, Toronto • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC