New antibody drug takes on advanced cancers in first human trial
NCT ID NCT05378425
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing a new drug called NTX-1088, which targets a protein on cancer cells, either alone or combined with the immunotherapy pembrolizumab. The study involves 90 people with advanced solid tumors that have spread or cannot be removed. The main goals are to find a safe dose and to see if the treatment can shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- NTX-1088 (a lab-made antibody targeting a protein on cancer cells) and pembrolizumab (an immunotherapy drug that helps the immune system attack cancer)
- What this could lead to
- If it works, this could point toward a new treatment option for people with advanced solid tumors that have not responded to other therapies.
- What could go wrong
- This is a very early (Phase 1) and small study, so the drug may not shrink tumors or could cause side effects. Success in this trial does not guarantee it will work for most patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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City of Hope
Duarte, California, 91010, United States
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Hadassah Medical Center
Jerusalem, 9574425, Israel
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Maria Skłodowska-Curie National Research Institute of Oncology
Warsaw, Poland
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Ochsner Clinic Foundation
New Orleans, Louisiana, 70121, United States
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Sheba Medical Center
Ramat Gan, 5262131, Israel
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The University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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